Results 1 to 10 of about 2,255,193 (285)

The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni [PDF]

, 2016
Natural selection acts on all organisms, including parasites, to maximise reproductive fitness. Drug resistance traits are often associated with life-history costs in the absence of treatment.
Viana, Mafalda, Faust, Christina L., Haydon, Dan T., Webster, Joanne P., Lamberton, Poppy H.L.   +4 more
core   +31 more sources

Therapeutic effect of demethylated hydroxylated phillygenin derivative on Helicobacter pylori infection

Frontiers in Microbiology, 2023
Modifying and transforming natural antibacterial products is a novel idea for developing new efficacious compounds. Phillygenin has an inhibitory effect on H. pylori.
Ru-Jia Li, Ru-Jia Li, Jia-yin Xu, Xue Wang, Li-juan Liao, Xian Wei, Ping Xie, Wen-yan Xu, Zhen-yi Xu, Shuo-hua Xie, Yu-ying Jiang, Liang Huang, Lu-yao Wang, Gan-rong Huang, Yan-Qiang Huang   +14 more
doaj   +1 more source

Dopamine Dynamics and Neurobiology of Non-Response to Antipsychotics, Relevance for Treatment Resistant Schizophrenia: A Systematic Review and Critical Appraisal

Biomedicines, 2023
Treatment resistant schizophrenia (TRS) is characterized by a lack of, or suboptimal response to, antipsychotic agents. The biological underpinnings of this clinical condition are still scarcely understood.
Felice Iasevoli, Camilla Avagliano, Luigi D’Ambrosio, Annarita Barone, Mariateresa Ciccarelli, Giuseppe De Simone, Benedetta Mazza, Licia Vellucci, Andrea de Bartolomeis   +8 more
doaj   +1 more source

Rhamnolipid-assisted black phosphorus nanosheets with efficient isolinderalactone loading against drug resistant Helicobacter pylori

Materials & Design, 2022
Oral administration remains the main treatment for H. pylori infection, but the acidic environment of the stomach, the biofilm and drug resistance of H. pylori severely impair the antibacterial effect of orally clinical drugs.
Yanqiang Huang, Rujia Li, Yuanyuan Dai, Chun Qin, Jikai He, Shixian Yang, Tengqi Wang, Yujie Su, Lizhou Jia, Wei Zhao   +9 more
doaj   +1 more source

Three New Xanthones from Hypericum scabrum and Their Quorum Sensing Inhibitory Activities against Chromobacterium violaceum

Molecules, 2022
Quorum sensing (QS) plays an important role in the production of virulence factors and pathogenicity in pathogenic bacteria and is, therefore, a hopeful target to fight against bacterial infections.
Li-Ping Teng, Hong Zeng, Cai-Yan Yang, He-Bin Wang, Zhong-Bo Zhou   +4 more
doaj   +1 more source

Antipsychotics-Induced Changes in Synaptic Architecture and Functional Connectivity: Translational Implications for Treatment Response and Resistance

Biomedicines, 2022
Schizophrenia is a severe mental illness characterized by alterations in processes that regulate both synaptic plasticity and functional connectivity between brain regions. Antipsychotics are the cornerstone of schizophrenia pharmacological treatment and,
Andrea de Bartolomeis, Giuseppe De Simone, Mariateresa Ciccarelli, Alessia Castiello, Benedetta Mazza, Licia Vellucci, Annarita Barone   +6 more
doaj   +1 more source

The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia

Biomolecules, 2023
Almost 25% of schizophrenia patients suffer from obsessive-compulsive symptoms (OCS) considered a transdiagnostic clinical continuum. The presence of symptoms pertaining to both schizophrenia and obsessive-compulsive disorder (OCD) may complicate ...
Licia Vellucci, Mariateresa Ciccarelli, Elisabetta Filomena Buonaguro, Michele Fornaro, Giordano D’Urso, Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Andrea de Bartolomeis   +8 more
doaj   +1 more source

Predictors of Treatment Resistance Across Different Clinical Subtypes of Depression: Comparison of Unipolar vs. Bipolar Cases

Frontiers in Psychiatry, 2020
ObjectiveTreatment-resistant depression (TRD) and treatment-resistant bipolar depression (TRBD) poses a significant clinical and societal burden, relying on different operational definitions and treatment approaches.
Michele Fornaro, Michele Fornaro, Andrea Fusco, Stefano Novello, Pierluigi Mosca, Annalisa Anastasia, Antonella De Blasio, Felice Iasevoli, Andrea de Bartolomeis   +8 more
doaj   +1 more source

Schizophrenia Synaptic Pathology and Antipsychotic Treatment in the Framework of Oxidative and Mitochondrial Dysfunction: Translational Highlights for the Clinics and Treatment

Antioxidants, 2023
Schizophrenia is a worldwide mental illness characterized by alterations at dopaminergic and glutamatergic synapses resulting in global dysconnectivity within and between brain networks.
Giuseppe De Simone, Benedetta Mazza, Licia Vellucci, Annarita Barone, Mariateresa Ciccarelli, Andrea de Bartolomeis   +5 more
doaj   +1 more source

Rational and Translational Implications of D-Amino Acids for Treatment-Resistant Schizophrenia: From Neurobiology to the Clinics

Biomolecules, 2022
Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of schizophrenia treatment and nearly all share the common feature of dopamine
Andrea de Bartolomeis, Licia Vellucci, Mark C. Austin, Giuseppe De Simone, Annarita Barone   +4 more
doaj   +1 more source