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Treatment-Resistant Depression: Approaches to Treatment
Journal of Psychosocial Nursing and Mental Health Services, 2021Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of first-line antidepressants and are considered to have treatment-resistant depression (TRD). Because the odds of remission decrease with every subsequent medication trial, it is important for clinicians to ...
Karan S, Kverno, Emma, Mangano
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Treatment-Resistant Schizophrenia
Psychiatric Clinics of North America, 2016Although treatment-resistant schizophrenia (TRS) was described 50 years ago and has a gold standard treatment with clozapine based on well-defined criteria, there is still a matter of great interest and controversy. In terms of the underlying mechanisms of the development of TRS, progress has been made for the elucidation of the neurochemical ...
Helio, Elkis, Peter F, Buckley
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Treatment‐resistant depression: resistant to definition?
Acta Psychiatrica Scandinavica, 2005Objective: To better define treatment‐resistant depression (TRD) so as to assist clinical management and refine treatment guidelines.Method: In this study, we examine a broad range of clinical variables in depressed patients (n = 196) referred to a tertiary referral Mood Disorders Unit (MDU).
G S, Malhi +4 more
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Treatment-Resistant Depression
Psychotherapy and Psychosomatics, 1998Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and
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Treatment Resistant Hypertension
American Journal of Therapeutics, 2008Treatment resistant hypertension is defined as a blood pressure not achieving a goal blood pressure (
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