Results 71 to 80 of about 2,255,193 (285)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, Volume 600, Issue 3, Page 342-355, February 2026.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Psychiatry and Clinical Psychopharmacology, 2017 OBJECTIVE: According to some studies, while first-generation antipsychotics were associated with slightly better outcomes and lower costs in comparison with second-generation antipsychotics, atypical antipsychotics have become the most commonly used ...
Saeed Shoja Shafti
doaj +1 more source
Restoration of Sensitivity in Chemo [PDF]
, 2013 Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite multimodal treatments including surgery, chemotherapy and radiotherapy the prognosis remains poor and relapse occurs regularly.
Boxhammer, Veronika +10 more
core +1 more source
Treatment-resistant prurigo nodularis.
Clinical, cosmetic and investigational dermatology, 2019 Sree S Kolli,1 Wasim Haidari,1 Steven R Feldman1–31Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA ...
Kolli,Sree +2 more
openaire +4 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Thyroid function test abnormalities in treatment-resistant schizophrenia
Psychiatry and Clinical Psychopharmacology, 2021 Objective: The relationship between thyroid dysfunction and mood disorders is well recognized. Thyroid function abnormalities are bad prognostic factors in mood disorders, and augmentation with thyroid hormone has therapeutic efficacy in treatment ...
Ertac Sertac Orsel +4 more
doaj
Trends in Psychiatry and Psychotherapy, 2020 Introduction Depression is one of the most important psychiatric disorders, and the rate of recurrence is high. The heavy cost burden of depression is probably due to treatment-resistant depression.
Aliakbar Foroughi +6 more
doaj +1 more source
Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]
, 2017 In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De +2 more
core +1 more source
Resistant and Refractory Hypertension: Antihypertensive Treatment Resistance vs Treatment Failure [PDF]
Canadian Journal of Cardiology, 2016 Resistant or difficult to treat hypertension is defined as high blood pressure that remains uncontrolled with 3 or more different antihypertensive medications, including a diuretic. Recent definitions also include controlled blood pressure with use of 4 or more medications as also being resistant to treatment.
Mohammed, Siddiqui +2 more
openaire +2 more sources