Results 31 to 40 of about 43,742 (227)

DETERMINING REFERENCE RANGES FOR TREC AND KREC ASSAYS IN IMMUNE DEFICIENCY SCREENING OF NEWBORNS IN RUSSIAN FEDERATION

Медицинская иммунология, 2019
In this work, we used a reference population of newborns and sampled dried blood spots on Guthrie cards of 2,739 individual samples to determine the reference intervals for TRECs and KRECs values, in order to diagnose primary immunodeficiency by means of
M. A. Gordukova, I. A. Korsunsky, Yu. V. Chursinova, M. M. Byakhova, I. P. Oscorbin, A. P. Prodeus, M. L. Filipenko   +6 more
doaj   +1 more source

Optimized workflow to modify microRNA expression in primary human intravascular cells

BMC Immunology, 2023
Background A comprehensive dissection of the role of microRNAs (miRNAs) in gene regulation and subsequent cell functions requires a specific and efficient knockdown or overexpression of the miRNA of interest; these are achieved by transfecting the cell ...
Safak Caglayan, John-Bjarne Hansen, Omri Snir   +2 more
doaj   +1 more source

Determining Laboratory Reference Values of TREC and KREC in Different Age Groups of Iranian Healthy Individuals

Iranian Journal of Allergy, Asthma and Immunology, 2019
Assessment of the number of T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) copies has been recently described as biomarkers of newly formed T and B cells respectively.
Leila Shakerian, Zahra Pourpak, Somayeh Shamlou, Erna Domsgen, Anoshirvan Kazemnejad, Hossein Dalili, Maryam Nourizadeh   +6 more
doaj   +1 more source

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia [PDF]

, 2004
We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell production through the thymus or from poor
Bingham, S.J., Brown, A.K., Buch, M., Douglas, S.H., Emery, P., Fearon, U., Field, S.L., Isaacs, J.D., Lawson, C.A., Ma, D., Maltby, S.L., Markham, A.F., Masurel, A., McGonagle, D., Moore, J., Morgan, A.W., Papadaki, H.A., Patel, P., Ponchel, F., Protheroe, A., Quinn, M., Short, K., Snowden, J., Straszynski, L., van Laar, J.M., Veale, D.J., Verburg, R.J.   +26 more
core   +2 more sources

TRECVID: benchmarking the effectiveness of information retrieval tasks on digital video [PDF]

, 2003
Many research groups worldwide are now investigating techniques which can support information retrieval on archives of digital video and as groups move on to implement these techniques they inevitably try to evaluate the performance of their techniques ...
Alan F. Smeaton, Alan F. Smeaton, See Profile   +2 more
core   +3 more sources

Newborn screening for severe combined immunodeficiency: lessons from a pilot study and prospects

Zdorovʹe Rebenka, 2023
The expansion of the neonatal screening program in Ukraine from October 2022 became an important achievement in the development of domestic medicine. Despite the severe challenges of the war and the burden of the COVID-19 pandemic, Ukraine was able to ...
O.R. Boyarchuk, N.M. Yarema, H.V. Makukh
doaj   +1 more source

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure [PDF]

, 2013
Extracellular heat-shock protein 72 (eHsp72) concentration increases during exercise-heat stress when conditions elicit physiological strain. Differences in severity of environmental and exercise stimuli have elicited varied response to stress.
A Asea, A Asea, A Asea, A Asea, A Burton, AG Pockley, Alex Dennis, AM Watkins, AP Gagge, AT Garrett, AT Garrett, AT Garrett, B Drust, B Nielsen, D Gagnon, DB Dill, DOF Canada, DS Moran, DS Moran, E Fehrenbach, E Fehrenbach, E Giraldo, E Ortega, EM Winter, F Amorim, FDC Magalhães, FT Amorim, G Borg, G Multhoff, GA Selkirk, GA Selkirk, GI Lancaster, GI Lancaster, GI Lancaster, HC Marshall, HH Kampinga, J Campisi, JD Johnson, JD Périard, JP McClung, JV Durnin, K Anbarasi, K Ogawa, KD Singleton, L Taylor, L Taylor, L Taylor, L Taylor, LA Mizzen, LB Rowell, Lee Taylor, LL Hom, M Fleshner, M Iguchi, M Whitham, M Whitham, MA Febbraio, ME Sandström, ME Sandström, MN Sawka, Neil S. Maxwell, Oliver R. Gibson, P-Z Lu, PA Ruell, Peter W. Watt, PM Yamada, R Duffield, R Morimoto, R Njemini, RC Walsh, RJ Maughan, RW Hubbard, S Lorenzo, S Lorenzo, SDR Galloway, SG Rhind, SN Cheuvront, Tony Parfitt, WE Siri, WJ Welch, Y Ogura, Y Oishi   +81 more
core   +1 more source

A case of early diagnosis of congenital multisystem langerhans cell histiocytosis with thymic involvement triggered by newborn screening

Immunological Medicine
T-cell receptor excision circle (TREC)-based newborn screening is a method for the early detection of severe combined immunodeficiency (SCID); however, undetectable TREC level results have also been reported in conditions other than SCID.
Yoji Uejima, Masayuki Iijima, Koichi Oshima, Ken Kawabata, Akihisa Nitta, Taiki Sato, Yoko Sato, Zenshiro Tamaki, Takahiro Hosokawa, Masaki Shimizu, Katsuyoshi Koh, Atsuko Nakazawa   +11 more
doaj   +1 more source

Клінічний випадок комбінованого імунодефіциту, діагностованого за допомогою визначення TREC

Сучасна педіатрія: Україна, 2022
Рання діагностика комбінованих імунодефіцитів (КІД) та вчасна терапія мають вкрай важливе значення для подальшого життя дитини. При народженні в дітей частіше немає специфічних ознак хвороби, проте вже з перших місяців життя можуть спостерігатися тяжкі ...
N.M. Yarema, H.V. Makukh, L.M. Virstyuk, O.V. Fedynska, O.R. Boyarchuk   +4 more
doaj   +1 more source

Newborn screening for severe combined immunodeficiency: feasibility, opportunities, and perspectives

Zdorovʹe Rebenka, 2020
Newborn screening is reasonable for rare conditions that cause serious health problems that are not defined by standard clinical examination but have effective methods of correction, and for which early diagnosis and treatment are important to achieve a ...
O.R. Boyarchuk
doaj   +1 more source