Results 31 to 40 of about 1,953,352 (249)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Site-specific oral microbiome profiles in healthy young Korean women
Scientific ReportsWe characterized site-specific organization of the oral microbiome in 59 healthy, non-smoking women in their twenties using 16S rRNA (V3–V4) sequencing of dental plaque (DQ), mouthwash (MW), and tongue coating (TC) samples (177 libraries; rarefied to 29 ...
Mu-Yeol Cho +8 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tree-Rings and Sunspot Numbers
, 1972 Tree-ring series that record climatic variation have long been of interest for study of possible effects of solar variability on terrestrial phenomena.
LaMarche, Valmore C., Jr. +1 more
core +5 more sources
Rowan Tree Church Annual Report, 1993 [PDF]
, 1993 This digital asset was created from the original digital scans by Rev. Paul V. Beyerl and provided to the Valdosta State University, Archives & Special Collections to be part of their Rowan Tree Church Periodicals Collection of the New Age Movements ...
Rowan Tree Church
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Rowan Tree Church. Annual Report, Hallows 1983-1984 ce [PDF]
, 1984 The Rowan Tree Church is an earth-based religion founded by Rev. Paul Beyerl, a Third Degree Initiate in the Alexandrian Tradition of Wicca, and incorporated on February 4, 1980 in Minneapolis, Minnesota.
Rowan Tree Church
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The Potential Health Benefits of Urban Tree Planting Suggested through Immersive Environments
LandDisruptive change in urban landscapes, such as large-scale tree planting, is complicated by the different priorities of the wide range of urban stakeholders.
Christopher Hassall +3 more
doaj +1 more source