Results 51 to 60 of about 877,649 (269)
Discrete Applied Mathematics, 2022 The study of structural graph width parameters like tree-width, clique-width and rank-width has been ongoing during the last five decades, and their algorithmic use has also been increasing [Cygan et al., 2015]. New width parameters continue to be defined, for example, MIM-width in 2012, twin-width in 2020, and mixed-thinness, a generalization of ...
Flavia Bonomo-Braberman +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On Trees with a Given Number of Vertices of Fixed Degree and Their Two Bond Incident Degree Indices
AxiomsThis paper is mainly concerned with the study of two bond incident degree (BID) indices, namely the variable sum exdeg index SEIa and the general zeroth-order Randić index Rα0.
Abeer M. Albalahi +6 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Auto-Configuration of ACL Policy in Case of Topology Change in Hybrid SDN
IEEE Access, 2016 Software-defined networking (SDN) has emerged as a new network architecture, which decouples both the control and management planes from data plane at forwarding devices.
Rashid Amin +3 more
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The Image of a Tree in F.M. Dostoyevsky's Novel "The Idiot" [PDF]
Достоевский и мировая культура: Филологический журнал, 2018 The article is devoted to the analysis of the image of a tree in Dostoevsky’s novel “The Idiot”. The author reflects on the evolution of this image from an artistic detail in the description of the Pavlovsk Park to the philosophical symbol of the Golden ...
Olga N. Smyslova
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IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2013 17 ...
Peter J. Humphries, Taoyang Wu
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source