Results 31 to 40 of about 73,689 (266)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Forest EcosystemsAs climate change intensifies, forests increasingly face the challenges posed by more frequent and severe droughts. However, the impacts of drought intensity on post-drought growth recovery and compensatory growth in trees remain poorly understood ...
Qiaoling Yang +8 more
doaj +1 more source
Frontiers in Forests and Global Change, 2020 The impact of ecological and climatological factors on individual organisms over time and space is inherently complex and creates substantial uncertainty about how climate change will influence the global biosphere. To understand some of this complexity,
Neil Pederson +9 more
doaj +1 more source
Nature Communications, 2022 A maximum latewood density based summer temperature reconstruction from eastern Canada shows recent warming is unprecedented over 1246 years, and tropical volcanism synchronizes regional and hemispheric summer temperatures at the multidecadal time scale.
Feng Wang +5 more
doaj +1 more source
Atmosphere, 2022 This work presents the results of a ten-year investigation (2010–2019) on the characteristics and sources of precipitation pollution in typical cities locating in the economic belt on the North Slope of Tianshan Mountain, Xinjiang. The water-soluble ions’
Yuting Zhong +5 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Unprecedented acceleration of winter discharge of Upper Yenisei River inferred from tree rings
Environmental Research Letters, 2021 The Yenisei River is the largest contributor of freshwater and energy fluxes among all rivers draining to the Arctic Ocean. Modeling long-term variability of Eurasian runoff to the Arctic Ocean is complicated by the considerable variability of river ...
Irina P Panyushkina +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source