Results 51 to 60 of about 265,624 (295)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Growth rings in tropical trees : role of functional traits, environment, and phylogeny [PDF]

, 2016
Acknowledgments Financial support of the Centre National de la Recherche Scientifique (USR 3330), France, and from the Rufford Small Grants Foundation (UK) is acknowledged.
Burslem, David F R P, Munoz, François, Muthusankar, G., Nath, Cheryl D., Pélissier, Raphaël   +4 more
core   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

DENDROCHRONOLOGICAL POTENTIAL OF JUNIPERUS EXCELSA (M.BIEB) FROM DRY TEMPERATE FOREST OF BALOCHISTAN PROVINCE, PAKISTAN

FUUAST Journal of Biology, 2011
Tree-rings are widely studied for determining tree ages, growth rates and reconstruction of thé past climate. Wood samples in the form of cross-sections and cores were obtained from 50 living Juniperus excelsa trees to determine their age, growth rates ...
ATTA MOHAMMAD SARANGZAI, ALIA AHMED
doaj  

Tracheid and Pit Dimensions Hardly Vary in the Xylem of Pinus sylvestris Under Contrasting Growing Conditions

Frontiers in Plant Science, 2021
Maintaining sufficient water transport via the xylem is crucial for tree survival under variable environmental conditions. Both efficiency and safety of the water transport are based on the anatomical structure of conduits and their connections, the pits.
Magdalena Held, Magdalena Held, Andrea Ganthaler, Anna Lintunen, Walter Oberhuber, Stefan Mayr   +5 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Old‐age pine trees: Unique objects of the Buzuluksky forest

Юг России: экология, развитие
Tree‐rings contain information about variability of climatic factors and about various negative events (abnormal weather events, fires, defoliation caused by leaf‐eating insects, etc.).Due to the fact that information about climatic conditions and ...
S. E. Kucherov, P. V. Velmovskiy
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Methodology for Development of a 600-Year Tree-Ring Multi-Element Record for Larch from the Taymir Peninsula, Russia [PDF]

Журнал Сибирского федерального университета: Серия Биология, 2013
We developed a long (600-year) dataset for the concentrations of 26 elements in tree rings of larch from the Taymir Peninsula, the northernmost region in the world (ca. 72°N) where trees grow. Tree rings corresponding to the time period from 1300 to 1900
Alexi M. Grachev, Eugene A. Vaganov, Steven W. Leavitt, Irina P. Panyushkina, Eugene P. Chebykin, Vladimir V. Shishov, Natalia A. Zhuchenko, Anastasia A. Knorre, Malcolm K. Hughes, Mukhtar M. Naurzbaev   +9 more
doaj