Results 51 to 60 of about 1,076,762 (310)

A New Method to Identify Incomplete Frame of Discernment in Evidence Theory

open access: yesIEEE Access, 2019
One assumption of Dempster-Shafer evidence theory (D-S theory) is the closed world. However, how to determine whether the frame of discernment is incomplete or not is still an open issue.
Renliang Sun, Yong Deng
doaj   +1 more source

The radial spanning tree of a Poisson point process

open access: yes, 2007
We analyze a class of spatial random spanning trees built on a realization of a homogeneous Poisson point process of the plane. This tree has a simple radial structure with the origin as its root.
Baccelli, Francois, Bordenave, Charles
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Reinforcement Learning via AIXI Approximation

open access: yes, 2010
This paper introduces a principled approach for the design of a scalable general reinforcement learning agent. This approach is based on a direct approximation of AIXI, a Bayesian optimality notion for general reinforcement learning agents.
Hutter, Marcus   +3 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Building trees by juggling information and following rules: an expert interview study on tree-building and phylogenetic inference

open access: yesEvolution: Education and Outreach
Tree-thinking is a fundamental skill set for understanding evolutionary theory and, thus, part of biological and scientific literacy. Research on this topic is mostly directed towards tree-reading—the umbrella-term for all skills enabling a person to ...
Steven Tyrrell, Philipp Schmiemann
doaj   +1 more source

Equitable Labelings of Caterpillar Graphs [PDF]

open access: yes, 2012
The Graceful Tree Conjecture in graph theory has been open for almost half a century. The conjecture states that the vertices of any tree can be labeled with distinct integers between 0 and the number of edges of the tree in a way that the edges can be ...
Burek, Mark   +2 more
core   +2 more sources

All Split Helicity Tree-Level Gluon Amplitudes

open access: yes, 2005
Recently a new recursion relation for tree-level gluon amplitudes in gauge theory has been discovered. We solve this recursion to obtain explicit formulas for the closed set of amplitudes with arbitrarily many positive and negative helicity gluons in a ...
Anastasia Volovich   +6 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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