Results 1 to 10 of about 20,481 (222)

Decoding thymic development: a single-cell atlas of tree shrew immunity [PDF]

Frontiers in Immunology
The tree shrew is a potential mammalian model for preclinical studies, but its immune system is not well understood. In this study, we utilized single-cell RNA sequencing (scRNA-seq) to construct a comprehensive cell atlas of the postnatal thymus ...
Haibo Tang, Haibo Tang, Yunlin He, Lifeng Zhang, Lifeng Zhang, Yingying Cao, Baoying Li, Baoying Li, Liang Liang, Liang Liang, Chengxia Yun, Chengxia Yun, Junyu Tao, Junyu Tao, Shanshan Zhai, Zhuxin Li, Yinghan Dai, Yanling Hu, Jing Leng, Jing Leng, Jing Leng   +20 more
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The Tree Shrew as a Model for Cancer Research [PDF]

Frontiers in Oncology, 2021
Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer.
Tao Lu, Hongmei Peng, Liping Zhong, Pan Wu, Jian He, Zhiming Deng, Yong Huang   +6 more
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Tree Shrew Is a Suitable Animal Model for the Study of Epstein Barr Virus [PDF]

Frontiers in Immunology, 2022
Epstein-Barr virus (EBV) is a human herpesvirus that latently infects approximately 95% of adults and is associated with a spectrum of human diseases including Infectious Mononucleosis and a variety of malignancies.
Wei Xia, Wei Xia, Honglin Chen, Honglin Chen, Yiwei Feng, Yiwei Feng, Nan Shi, Nan Shi, Zongjian Huang, Zongjian Huang, Qingyuan Feng, Qingyuan Feng, Xu Jiang, Xu Jiang, Guangyao He, Guangyao He, Mao Xie, Mao Xie, Yongjin Lai, Yongjin Lai, Zhi Wang, Zhi Wang, Xiang Yi, Xiang Yi, Anzhou Tang, Anzhou Tang   +25 more
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Optimizing procedures for ocular radiation injury studies in the tree shrew [PDF]

Exploration of Targeted Anti-tumor Therapy
Radiation exposure to the eye during cancer treatment can lead to ocular radiation injury (ORI), a devastating condition that can have a profound and permanent impact on vision-related quality of life. Rodent models do not have adequate ocular anatomy to
Lauren A. Dalvin, Kjersten J. Anderson, Tommy A. Rinkoski, David R. Miley, Hien Ong, Angela M. Schechinger, Cassandra A. Fjeld, Catherine R. Leblond, Mackenzie K. Keown, Sierra D. Palmer, Danielle M. Burgenske, Brett L. Carlson, Lauren L. Ott, Brian C. Samuels, Michael F. Romero, Jann N. Sarkaria, Felicia Duke Boynton, Gavin W. Roddy   +17 more
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Identification and characterization of the tumor necrosis factor receptor superfamily in the Chinese tree shrew (Tupaia belangeri chinensis) [PDF]

BMC Genomics
The tumor necrosis factor receptor superfamily (TNFRSF) plays a vital role in eliciting immune responses against infections. The tree shrew, closely related to primates, is often utilized in human disease models.
Zongjian Huang, Nan Shi, Zhenqiu Luo, Fangfang Chen, Xunwei Feng, Yongjing Lai, Jian Li, Xiang Yi, Wei Xia, Anzhou Tang   +9 more
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Tree shrew as a new animal model for musculoskeletal disorders and aging [PDF]

Bone Research
Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-related risk factors, representing the leading causes of disability.
Xiaocui Wei, Honghao Li, Jingyang Qiu, Jianlin Jiao, Xiongtian Guo, Gaosheng Yin, Ping Yang, Yi Han, Qiongzhi Zhao, Hao Zeng, Zhi Rao, Xuefei Gao, Kai Li, Pinglin Lai, Sheng Zhang, Chengliang Yang, Di Lu, Xiaochun Bai   +17 more
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Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation [PDF]

BMC Biology
Background The tree shrew (Tupaia belangeri) is a promising emerging model organism in biomedical studies, notably due to their evolutionary proximity to primates.
Dongmin R. Son, Yifan Kong, Yulian Tan, Ting Hu, Lei Shi, Soojin V. Yi   +5 more
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Molecular Characterization and Function of the Nogo-66 Receptor (NgR1) Gene in the Chinese Tree Shrew

Journal of Integrative Neuroscience, 2023
Background: Nogo-66 receptor (NgR1) is a glycosylphosphatidylinositol-linked cell surface receptor with high affinity for Nogo-66. The binding of Nogo-66 to NgR1 plays a key role in inhibiting neurite growth, limiting synaptic plasticity and mediating ...
Caixia Lu, Xiuying Kui, Xiaofei Li, Wenguang Wang, Xiaomei Sun, Na Li, Pinfen Tong, Jiejie Dai   +7 more
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First report of Schistosoma sinensium infecting Tupaia belangeri and Tricula sp. LF

International Journal for Parasitology: Parasites and Wildlife, 2021
Schistosoma sinensium belongs to the Asian Schistosoma and is transmitted by freshwater snails of the genus Tricula. Rodents are known definitive hosts of S. sinensium.
Xuan Wang, Leiying Ruan, Qingkai Song, Wenguang Wang, Pinfen Tong, Dexuan Kuang, Caixia Lu, Na Li, Yuanyuan Han, Jiejie Dai, Xiaomei Sun   +10 more
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Identification, characterization and expression profiles of PSEN2 in the Chinese tree shrew (Tupaia belangeri chinensis) [PDF]

Journal of Integrative Neuroscience, 2020
The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase. Mutations in PSEN2 are not only related to Alzheimer's disease but are also involved in other diseases.
Mingxue Li, Wenguang Wang, Dexuan Kuang, Leiying Ruan, Xiaohui Li, Xin Huang, Xiaomei Sun, Jiejie Dai, Caixia Lu
doaj   +1 more source