Results 1 to 10 of about 20,445 (217)

The Tree Shrew as a Model for Cancer Research [PDF]

Frontiers in Oncology, 2021
Animal disease models are necessary in medical research, and an appropriate animal model is of great importance for studies about the prevention or treatment of cancer.
Tao Lu, Hongmei Peng, Liping Zhong, Pan Wu, Jian He, Zhiming Deng, Yong Huang   +6 more
doaj   +5 more sources

Body surface area-based equivalent dose calculation in tree shrew

Science Progress, 2021
Tree shrew (Tupaia belangeri) is a promising experimental animal in biomedical research, but the equivalent doses of drugs between tree shrew and human and other animals has not been explored, which hinders its further application in a wider scope.
Wei Xia, Zong-Jian Huang, Yi-Wei Feng, An-Zhou Tang, Lei Liu   +4 more
doaj   +2 more sources

Decoding thymic development: a single-cell atlas of tree shrew immunity [PDF]

Frontiers in Immunology
The tree shrew is a potential mammalian model for preclinical studies, but its immune system is not well understood. In this study, we utilized single-cell RNA sequencing (scRNA-seq) to construct a comprehensive cell atlas of the postnatal thymus ...
Haibo Tang, Haibo Tang, Yunlin He, Lifeng Zhang, Lifeng Zhang, Yingying Cao, Baoying Li, Baoying Li, Liang Liang, Liang Liang, Chengxia Yun, Chengxia Yun, Junyu Tao, Junyu Tao, Shanshan Zhai, Zhuxin Li, Yinghan Dai, Yanling Hu, Jing Leng, Jing Leng, Jing Leng   +20 more
doaj   +2 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target [PDF]

Animal Models and Experimental Medicine
Background Diabetic retinopathy (DR) is the most significant manifestation of diabetic microangiopathy. The existing tree shrew model of DR has dysfunctional retinal short wave sensitivity (SWS) cones and retinal ganglion cells, but it remains unclear ...
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
doaj   +2 more sources

Cross-sectional atlas of the tree shrew (Tupaia belangeri) head, neck, and trunk: a comparison of micro-CT imaging and cadaveric sections [PDF]

Frontiers in Veterinary Science
IntroductionTree shrews are widely used as animal models in various research fields, however, a comprehensive cross-sectional anatomic reference for this species is currently lacking.MethodsIn this study, Conventional Micro-CT scanning (40 μm slice ...
Fangfang Chen, Fangfang Chen, Yiwei Feng, Yiwei Feng, Nan Shi, Nan Shi, Pengcheng Zhao, Pengcheng Zhao, Zongjian Huang, Zongjian Huang, Yu Ren, Yu Ren, Wei Xia, Wei Xia, Anzhou Tang, Anzhou Tang   +15 more
doaj   +2 more sources

Optimizing procedures for ocular radiation injury studies in the tree shrew [PDF]

Exploration of Targeted Anti-tumor Therapy
Radiation exposure to the eye during cancer treatment can lead to ocular radiation injury (ORI), a devastating condition that can have a profound and permanent impact on vision-related quality of life. Rodent models do not have adequate ocular anatomy to
Lauren A. Dalvin, Kjersten J. Anderson, Tommy A. Rinkoski, David R. Miley, Hien Ong, Angela M. Schechinger, Cassandra A. Fjeld, Catherine R. Leblond, Mackenzie K. Keown, Sierra D. Palmer, Danielle M. Burgenske, Brett L. Carlson, Lauren L. Ott, Brian C. Samuels, Michael F. Romero, Jann N. Sarkaria, Felicia Duke Boynton, Gavin W. Roddy   +17 more
doaj   +2 more sources

Infectivity of Zika virus on primary cells support tree shrew as animal model

Emerging Microbes and Infections, 2019
Zika virus (ZIKV) is a mosquito-borne flavivirus that caused the public health emergency. Recently, we have proved a novel small animal tree shrew was susceptive to ZIKV infection and presented the most common rash symptoms as ZIKV patients.
Li Zhang, Zhi-Li Shen, Yue Feng, Dao-Qun Li, Na-Na Zhang, Yong-Qiang Deng, Xiao-Peng Qi, Xiao-Mei Sun, Jie-Jie Dai, Chun-Guang Yang, Zi-Feng Yang, Cheng-Feng Qin, Xue-Shan Xia   +12 more
doaj   +3 more sources

Tree Shrew Is a Suitable Animal Model for the Study of Epstein Barr Virus [PDF]

Frontiers in Immunology, 2022
Epstein-Barr virus (EBV) is a human herpesvirus that latently infects approximately 95% of adults and is associated with a spectrum of human diseases including Infectious Mononucleosis and a variety of malignancies.
Wei Xia, Wei Xia, Honglin Chen, Honglin Chen, Yiwei Feng, Yiwei Feng, Nan Shi, Nan Shi, Zongjian Huang, Zongjian Huang, Qingyuan Feng, Qingyuan Feng, Xu Jiang, Xu Jiang, Guangyao He, Guangyao He, Mao Xie, Mao Xie, Yongjin Lai, Yongjin Lai, Zhi Wang, Zhi Wang, Xiang Yi, Xiang Yi, Anzhou Tang, Anzhou Tang   +25 more
doaj   +2 more sources

Identification and characterization of the tumor necrosis factor receptor superfamily in the Chinese tree shrew (Tupaia belangeri chinensis) [PDF]

BMC Genomics
The tumor necrosis factor receptor superfamily (TNFRSF) plays a vital role in eliciting immune responses against infections. The tree shrew, closely related to primates, is often utilized in human disease models.
Zongjian Huang, Nan Shi, Zhenqiu Luo, Fangfang Chen, Xunwei Feng, Yongjing Lai, Jian Li, Xiang Yi, Wei Xia, Anzhou Tang   +9 more
doaj   +2 more sources

Tree shrew as a new animal model for musculoskeletal disorders and aging [PDF]

Bone Research
Intervertebral disc degeneration (IDD), osteoarthritis (OA), and osteoporosis (OP) are common musculoskeletal disorders (MSDs) with similar age-related risk factors, representing the leading causes of disability.
Xiaocui Wei, Honghao Li, Jingyang Qiu, Jianlin Jiao, Xiongtian Guo, Gaosheng Yin, Ping Yang, Yi Han, Qiongzhi Zhao, Hao Zeng, Zhi Rao, Xuefei Gao, Kai Li, Pinglin Lai, Sheng Zhang, Chengliang Yang, Di Lu, Xiaochun Bai   +17 more
doaj   +2 more sources