Results 41 to 50 of about 1,723,261 (194)

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Redefining the Role of Splenectomy in Scirrhous Gastric Cancer: Toward a Selective Multimodal Strategy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Scirrhous gastric cancer, characterized by diffuse infiltration and a high propensity for peritoneal dissemination, remains one of the most aggressive subtypes of gastric cancer. Despite a relatively high incidence of splenic hilar lymph node (No. 10) metastasis, the oncologic benefit of splenectomy remains controversial, while its association
Tsutomu Hayashi, Takaki Yoshikawa
wiley   +1 more source

Early Head Tremor in Essential Tremor: A Case Series and Commentary [PDF]

, 2017
Background: Classically, the onset of head tremor in essential tremor (ET) patients follows that of hand tremor, such that there is a somatotopic spread of involved areas.
Elan D. Louis, James Meyers, Lorraine N. Clark, Naranjo, Kelly V., Louis, Elan D., Cristal, Ashley D., Park, Jemin, Ashley D. Cristal, Karen P. Chen, Nora Hernandez, Meyers, James, Jemin Park, Hernandez, Nora, Chen, Karen P., Badejo, Funmi M., Clark, Lorraine N., Kelly V. Naranjo, Funmi M. Badejo   +17 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Abrupt Suppression of Tectonic Tremors Outside the Stress Shadow of Mendocino Earthquakes

Geophysical Research Letters
Tectonic tremor is a long‐duration noise‐like seismic signal associated with slow fault motion at major plate boundaries. Due to their remarkable sensitivity to stress perturbations, tremors serve as invaluable probes of the mechanical state and stress ...
Weifan Lu, Satoshi Ide, Chunmei Ren
doaj   +1 more source

Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor [PDF]

, 2012
Background: Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature.
Handforth, Adrian, Adrian Handforth
core   +1 more source

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy

Epileptic Disorders, EarlyView.
Abstract Background and Objectives KBG syndrome is a rare autosomal developmental disorder caused by pathogenic variants of the ANKRD11 gene. This scoping review aimed to explore all current literature data regarding clinical and electroencephalographic features of patients with KBG syndrome and epilepsy. Materials and Methods We conducted a literature
Stefania Kalampokini, Evripidis Pityrigkas, Zoi Kallia, Georgia Pepe, Antonis Frontistis, Dimitrios Profer, Vasilios Kimiskidis   +6 more
wiley   +1 more source

Deep Seismic Tremors in the 2025 Santorini Seismo‐Volcanic Crisis Highlight Magmatic Feeding From a Mid‐Crustal Reservoir

Geophysical Research Letters
An intense seismic swarm started on 27 January 2025 in the Santorini‐Amorgos region and lasted for approximately 45 days. A widely observed seismic tremor on 14 February 2025 suggested a volcanic origin for the 2025 Santorini crisis.
Jean Soubestre, Jannes Münchmeyer, Quentin Higueret, Nikolai M. Shapiro, Florent Brenguier, Anthony Lomax   +5 more
doaj   +1 more source

Complex characteristics of slow slip events in subduction zones reproduced in multi‐cycle simulations

Geophysical Research Letters, 2012
Since the discovery of slow slip events along subduction zone interfaces worldwide, dense geodetic and seismic networks have illuminated detailed characteristics of these events and associated tremor.
Harmony V. Colella, James H. Dieterich, Keith Richards‐Dinger, Allan M. Rubin   +3 more
doaj   +1 more source