Results 51 to 60 of about 1,723,261 (194)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Tectonic Tremor Reveals Slow Deformation Along the Antarctic–South American Subduction Zone

Geophysical Research Letters
The Antarctic–South American subduction zone is among the least explored convergent margins and lacks documented large interplate earthquakes despite ongoing convergence.
K. Azúa, S. Ruiz, S. Ide
doaj   +1 more source

Dystonic Head Tremor and the Coexistence of Headache [PDF]

, 2017
Background: Head tremor may be observed in the presence of cervical dystonia and sometimes coexists with headache. We wished to investigate the presence of headache in dystonic head tremor.Methods: We studied the files of 19 patients from our ...
Marit A. Hulzenga, Koehler, Peter J., Debbie Beumer, Peter J. Koehler, Hulzenga, Marit A., Beumer, Debbie   +5 more
core   +1 more source

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

NEUROLOGICAL DISORDER AMONG PREMUTATION CARRIERS OF FRAGILE X SYNDROME AT SEMIN, GUNUNG KIDUL REGENCY [PDF]

, 2010
Background: Neurological disorder among male premutation carriers of Fragile X Syndrome (FXS) frequently occurs. In other hand, lacking of information results misdiagnosis of this disorder.
Ardiansyah, Rivaldi
core   +1 more source

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

Exploration, EarlyView.
Chronic stressors trigger systemic immune remodeling marked by myeloid expansion and lymphoid suppression, and this immune imbalance subsequently drives tissue pathology through proinflammatory signaling and senescence amplification, with the lung and kidney confirmed as the most vulnerable target organs.
Mengnan Li, Zheming Chen, Lu Wang, Zixuan Wang, Shixiong Zhang, Kunxu Niu, Xiaogang Shen, Xuan Lu, Runtao Zhang, Yuning Jiang, Yawen Li, Yi Dai, Xiyang Tang, Bin Hou, Min Shi, Xiaoya Wang, Zhifang Guo, Xingyu Xing, Ning Kang, Hongrong Li, Tianyu Kang, Evelyne Bischof, Yunlong Hou, Zhenhua Jia   +23 more
wiley   +1 more source

Geophysical Constraints on the Relationship Between Seamount Subduction, Slow Slip, and Tremor at the North Hikurangi Subduction Zone, New Zealand

Geophysical Research Letters, 2018
We use a prestack depth migration reflection image and magnetic anomaly data across the northern Hikurangi subduction zone, New Zealand, to constrain plate boundary structure and geometry of a subducting seamount in a region of shallow slow slip and ...
Daniel H. N. Barker, Stuart Henrys, Fabio Caratori Tontini, Philip M. Barnes, Dan Bassett, Erin Todd, Laura Wallace   +6 more
doaj   +1 more source

A Rare Presentation of Orthostatic Tremor as Abdominal Tremor [PDF]

, 2018
Background: Orthostatic tremor (OT) is a weight-bearing hyperkinetic disorder characterized by unsteadiness while standing that is relieved when sitting or walking. Case report: A 66-year-old male presented with a 5 year-history of tremor in his abdomen,
Mousele, Christina, Christina Mousele, Paul Bentley, Tai, Yen F., Tai, Yen Foung, Bentley, Paul, Yen F. Tai   +6 more
core   +1 more source

Programmable crack dynamics engineering enables flexible strain sensors with high linearity

FlexMat, EarlyView.
First‐decoupling theoretical framework of crack evolution elucidating the control methods, mechanistic insights, and structure‐activity relationships is established. Crack propagation from uncontrollable randomness systematically evolves into spatially ordered states.
Chunjin Wu, Shaolong Wang, Xu Wang, Heng Zhu, Yongliang Tian, Xinchen Jiang, Xin Rao, Yutong Han, Changrun Wang, Wen‐Yong Lai   +9 more
wiley   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source