Results 91 to 100 of about 240,547 (357)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Effects of Landslides on the Safety of Roads and Rural Settlements in Iran and Stabilization Methods (Case Study of Naghan-Karoon 4 Road Landslides) [PDF]
مسکن و محیط روستا, 2017 This study investigates landslides occurred in Chahar Mahal – Bakhtiari Province in Iran, using a probability analysis for describing landslide mechanism. Two case studies of landslide in this province (Naghan – karoon 4 Road) are analyzed using software
Mohsen Salehi +3 more
doaj
Des chevaux sous l’Occupation : le charnier du site archéologique des Varennes à Bar-sur-Aube (Aube)
In Situ, 2015 Horses under the Occupation, the mass grave at the Varennes archaeological at Bar-sur-Aube (Aube). The discovery in 2013, at Bar-sur-Aube of a trench filled with more than forty carcasses of horses, led the team of archaeologists who made this discovery ...
Gilles Deborde
doaj +1 more source
Horizontal mantle flow controls subduction dynamics [PDF]
, 2017 It is generally accepted that subduction is driven by downgoing-plate negative buoyancy. Yet plate age –the main control on buoyancy– exhibits little correlation with most of the present-day subduction velocities and slab dips. “West”-directed subduction
Dal Zilio, Luca +3 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Teenagers’ Expectations of Applying to University: How do they Change?
Education Sciences, 2015 We show how young people’s expectations about application to university change during the teenage years, drawing on the Longitudinal Study of Young People in England (LSYPE).
Jake Anders, John Micklewright
doaj +1 more source