Results 111 to 120 of about 2,439,891 (316)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Deciphering multiway multiscale brain network connectivity from birth to 6 months
Communications BiologyConverging evidence suggests that understanding the human brain requires more than just examining pairwise functional brain interactions. The human brain is a complex, nonlinear system, and focusing solely on linear pairwise functional connectivity often
Qiang Li +7 more
doaj +1 more source
Frontiers in NeuroscienceIntroductionThe Integration of functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) has allowed for a novel exploration of the brain’s spatial–temporal resolution.
Souvik Phadikar +3 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Inclusive Storytelling: Immigrant Experiences and Community Reaction in Georgia
Journal of Community Engagement and ScholarshipThrough examination of a multiyear, interdisciplinary, qualitative, community-based participatory research project that began in 2017, this paper explores the role of storytelling in the transference of knowledge, history, and sense of purpose ...
Darlene Xiomara Rodriguez +3 more
doaj +1 more source
Biblioteche oggi Trends è la serie della rivista Biblioteche oggi, che si propone di svolgere un’attività di studio e ricerca nell’ambito della biblioteconomia e della scienza dell’informazione con particolare attenzione alle nuove tendenze e al ...
Lucia Sardo
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Reaction-diffusion model for brain spacetime dynamics
Biophysical ReportsThe human brain exhibits intricate spatiotemporal dynamics, which can be described and understood through the framework of complex dynamic systems theory.
Qiang Li, Vince D. Calhoun
doaj +1 more source