Results 101 to 110 of about 6,114,826 (359)
Trends in GPCR drug discovery: new agents, targets and indications
Nature reviews. Drug discovery, 2017 G protein-coupled receptors (GPCRs) are the most intensively studied drug targets, mostly due to their substantial involvement in human pathophysiology and their pharmacological tractability.
A. Hauser +4 more
semanticscholar +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Trends in Amplification, 2006 The population older than age 65 is increasing and is expected to increase even more in the next 50 years. In the more developed regions of the world, current life expectancy is approximately 76 years, 10 years longer than life expectancy in 1950. By the year 2050, the projected life expectancy will be 82 years.
openaire +2 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
NeuroImageIn recent years, deep learning approaches have gained significant attention in predicting brain disorders using neuroimaging data. However, conventional methods often rely on single-modality data and supervised models, which provide only a limited ...
Alex Fedorov +10 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Trends in inorganic instrumental analysis
, 1998 A report on the Workshop "Trends in Inorganic Instrumental Analysis", held in Zurich, 7-8 July ...
Moor, Christoph (author)
core +1 more source
Trends in thyroid cancer incidence and mortality in the United States, 1974–2013
Journal of the American Medical Association (JAMA), 2017 Importance Thyroid cancer incidence has increased substantially in the United States over the last 4 decades, driven largely by increases in papillary thyroid cancer.
Hyeyeun Lim +4 more
semanticscholar +1 more source
To say or not to say. The importance of being transparent in retail branding
, 2016 In the age of sharing and social media, brands are increasingly being called upon to meet consumers’ demand for transparency. Over the past decades Store Brands (SBs) have increased both their market share and customer loyalty internationally; thus it is
Francesca Negri +8 more
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