Results 91 to 100 of about 6,114,826 (359)
International Journal of Child Care and Education PolicyIn the United States, many children ages 3–5 are enrolled in preschool. Preschool occurs prior to kindergarten, which is the first year of free universal public school education, but is optional in all locales and often operates separately from the free ...
Kyle DeMeo Cook +5 more
doaj +1 more source
Global Cancer Incidence and Mortality Rates and Trends—An Update
Cancer Epidemiology, Biomarkers and Prevention, 2015 There are limited published data on recent cancer incidence and mortality trends worldwide. We used the International Agency for Research on Cancer's CANCERMondial clearinghouse to present age-standardized cancer incidence and death rates for 2003–2007 ...
Lindsey A. Torre +3 more
semanticscholar +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Theoria cum Praxi? The (In-) Compatibility of Demands in Science and Business World
Forum: Qualitative Social Research, 2004 The necessity for co-operation between (scientific) theory and (management) praxis is apparent more than ever. There are countless parallels in the goals and objectives of social and marketing research, for example, learning more about communities ...
Monika Kritzmöller
doaj
Semantic locality-aware biclustering for brain functional network connectivity
Scientific ReportsFunctional connectivity (FC) has become central to understanding human brain dynamics and a reliable pursuit for investigating neuropsychiatric disorders.
Md Abdur Rahaman +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
NeuroImageBrain disorders are often associated with changes in brain structure and function, where functional changes may be due to underlying structural variations.
Yuda Bi +4 more
doaj +1 more source
Recombinant Hepatitis B surface antigen vaccines for the delivery of disease-related antigens.
, 2008 The extraordinary immunogenicity of the envelope protein of Hepatitis B virus (HBsAg) has been exploited to derive the pan-global vaccine to prevent Hepatitis B virus infection.
Scott Thomson +3 more
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source