Results 31 to 40 of about 759 (101)

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer

Cancer Science, EarlyView.
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka, Koji Hatano, Shohei Katsuki, Tomohiro Kanaki, Shunsuke Inoguchi, Masaru Tani, Akihiro Yoshimura, Yuki Horibe, Yutong Liu, Nesrine Sassi, Yohei Okuda, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Keisuke Tamari, Bangzhong Lin, Akiyoshi Tani, Kazutake Tsujikawa, Yutaka Takahashi, Kazuhiko Ogawa, Shawn E. Lupold, Norio Nonomura   +26 more
wiley   +1 more source

Influence of Peptide‐Based Chelator Sequences on HER2‐Targeting Radiopeptide

Journal of Peptide Science, Volume 32, Issue 5, May 2026.
Peptide‐based chelator consisting of Cys‐Gly‐Gly‐Gly incorporated into HER2‐targeting rL‐A9 peptide for 99mTc‐labeling. [99mTc]Tc‐CGGG‐rL‐A9 exhibited high binding affinity and tumor uptake and retention. ABSTRACT In our pursuit of developing HER2‐targeting radiolabeled peptides for detection and therapy of HER2‐positive breast cancer, the previously ...
Sonal Gupta, Manoj Kumar, Krishna Mohan Repaka, Amit Das, Ajit A. Kengar, Drishty Satpati   +5 more
wiley   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, Volume 73, Issue 3, March 2026.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Enhanced Thermodynamic Stability of UO22+ Complex Through Structure Preorganization of N3O2‐Pentadentate Planar Ligand for Uranium Harvesting from Seawater

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Thanks to the appropriate structure preorganization of an N3O2‐pentadentate planar ligand, 2,6‐bis(2‐hydroxyphenylmethylaminomethyl)pyridine (H2saldamp) exhibits the strongest coordination affinity to UO22+ (log βU = 33.60) compared to ligands developed for uranium harvesting from seawater to date, as well as good separability of UO22+ from other metal
Ryuto Nabata, Satoru Tsushima, Koichiro Takao   +2 more
wiley   +1 more source

Tracking early cognitive decline in preclinical AD with brain MRI similarity

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Early detection of neuroanatomical changes in preclinical Alzheimer's disease (AD) is critical for timely intervention. However, conventional magnetic resonance imaging (MRI) and fluid biomarkers often lack sensitivity to subtle structural alterations in early disease stages. METHODS To identify early brain alterations, we applied
Jiawei Sun, Blanca Zufiria‐Gerbolés, Massimiliano Passaretti, Giovanni Volpe, Mite Mijalkov, Joana B. Pereira, for the Alzheimer's Disease Neuroimaging Initiative   +6 more
wiley   +1 more source

Integrating real‐world data with gold‐standard longitudinal clinical and genomic data to advance precision medicine for the Alzheimer's Disease Research Center Program and beyond: a proof‐of‐concept data platform

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Integrating real‐world data (RWD) with clinical research datasets creates more complete, context‐rich resources to drive discovery and enable precision medicine in Alzheimer's disease and related dementias. The National Alzheimer's Coordinating Center conducted a proof‐of‐concept (POC) project to link its longitudinal Uniform Data
Sarah Biber, Jessica E. Culhane, Maria G. Prado, Satish Mathew, Yohali Burrola‐Mendez, Imara I. West, Sarah Van Heiden, Jimmy Phuong, Shilpa Allimatti, Liam G. Lane, Krista L. Moulder, Brittany K. Hale, Amanda Kuzma, Li‐San Wang, Sujuan Gao, Albert Lai, Karthik Natarajan, Sophia Wang, John C. Morris, James M. Noble, Sean D. Mooney, Walter Kukull, Andrew J. Saykin, Kari A. Stephens   +23 more
wiley   +1 more source

Tau PET overlap index correlation with neuropathological findings

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION The tau positron emission tomography (PET) overlap index (OI) has shown promise in maximizing signal‐to‐noise for longitudinal tau PET imaging, particularly for early tau pathology, but requires validation against neuropathology.
Seokbeen Lim, Jeyeon Lee, Paul H. Min, Christina M. Moloney, Carly T. Mester, Sujala Ghatamaneni, Matthew L. Senjem, Hugo Botha, David S. Knopman, Stuart J. McCarter, Vijay K. Ramanan, Rodolfo Savica, Julie A. Fields, Mary M. Machulda, Dennis W. Dickson, R. Ross Reichard, Aivi T. Nguyen, Jonathan Graff‐Radford, Christopher G. Schwarz, Jeffrey L. Gunter, Kejal Kantarci, Bradley Boeve, Prashanthi Vemuri, David T. Jones, Clifford R. Jack Jr., Ronald C. Petersen, Melissa E. Murray, Val J. Lowe   +27 more
wiley   +1 more source

Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 1, March 2026.
Abstract INTRODUCTION Relationships between Alzheimer's disease neuropathology, residential neighborhood, and cognitive impairment remain incompletely understood. METHODS We examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity.
Charles C. Windon, Elena Tsoy, Jennifer Livaudais‐Toman, Torsten B. Neilands, Nynikka R. Palmer, Margo B. Heston, Julene K. Johnson, Lucy Hanna, Constantine Gatsonis, Justin Romanoff, Jon Steingrimsson, Maria C. Carrillo, Peggye Dilworth‐Anderson, Bruce E. Hillner, Barry A. Siegel, Rachel A. Whitmer, Consuelo H. Wilkins, Karen Smith, Ganna Blazhenets, Renaud La Joie, Bruce L. Miller, Katherine L. Possin, Gil D. Rabinovici   +22 more
wiley   +1 more source

Mausolate Complexes of the Alkaline Earth Metals

ChemistryEurope, Volume 4, Issue 3, March 2026.
Reliable chelation of Ra2+ for radionuclide therapy has long been a challenge, and the capacious and rigid mausolate ligand may offer a promising approach. We describe herein mausolate complexes with the chemically similar Ba2+, and other group 2 dications, including the introduction of functionalized derivatives. The rapid uptake of alkaline earth (Ae)
Jack F. Smart, Liam D. N. Krueckl, R. Quinn Schmidt, Leah Gajecki, Lindsey E. K. Frederiksen, Allen G. Oliver, David J. Berg, J. Scott McIndoe   +7 more
wiley   +1 more source

Synthesis, Radiochemical Characterization, and Biodistribution of a 188Re Analogue of [131I]mIBG in a Neuroblastoma Xenograft Model

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 3, March 2026.
A 188Re analogue of [131I]mIBG was synthesized in moderate yields using 188Re‐4 + 1 chemistry. In vitro studies using SK‐N‐SH neuroblastoma cell lines demonstrated that the compound exhibited affinity for norepinephrine transporters expressed on these cancer cells.
Navin Sakhare, Dheeraj Kumar, Soumen Das, Arpit Mitra, Shubhangi Mirapurkar, G. Rani, M. Sheela, Viju Chirayil, Bhabani Mohanty, Anupam Mathur, Madhava B. Mallia, Pradip Chaudhari   +11 more
wiley   +1 more source