Results 41 to 50 of about 797 (106)

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]‐SMBT‐1 Positron‐Emission Tomography

Glia, Volume 74, Issue 8, August 2026.
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Lewis S. Crawford, James W. M. Kang, OIivia I. Davanzo, Hyunsol Lim, Sabrina Salberg, Marissa Srgo, Crystal Li, Gaelle M. Emvalomenos, Bianca Jupp, Matthew Long, Wayne Noonan, Mohammad B. Haskali, Richelle Mychasiuk, Kevin A. Keay, Luke A. Henderson   +14 more
wiley   +1 more source

Alzheimer's Biomarkers and Visuospatial Cognition in Parkinson's Disease: Modification by α‐Synuclein and Mediation of Age Effects

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1861-1875, August 2026.
Abstract Background Visuospatial deficits in Parkinson's disease (PD) often precede dementia and complicate daily functioning. Alzheimer's disease (AD) pathology and α‐synuclein aggregation frequently co‐occur in PD, but their combined impact on cognition is unclear.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Meher Lad, Mark R. Baker, Nicola Pavese   +8 more
wiley   +1 more source

Characterization and calibration of the iQID digital autoradiography system for direct quantitative imaging of beta‐emitters in tissue samples

Medical Physics, Volume 53, Issue 8, August 2026.
Abstract Background Autoradiography provides microscale mapping of radionuclide distributions, offering a promising approach to complement nuclear medicine imaging for small‐scale radiopharmaceutical therapy (RPT) research. However, while quantitative protocols for α‐emitters are well‐established, comparable methods for β‐emitters, such as the widely ...
Ohyun Kwon, Sean P. Jollota, Adedamola O. Adeniyi, Justin J. Jeffery, Joseph B. Schulz, Lauren E. Wehner, Malick Bio Idrissou, Eduardo Aluicio‐Sarduy, Brian W. Miller, Denis E. Bergeron, Reinier Hernandez, Larry A. DeWerd, Bryan P. Bednarz   +12 more
wiley   +1 more source

Post‐Marketing Requirements for Anticancer Drugs Approved in Japan, 2001–2024: A Cross‐Sectional Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT The accelerated development of innovative anticancer therapies has led to the early approval of an increasing number of drugs. However, clinical evidence available at the time of approval is often limited, necessitating additional post‐marketing studies to supplement safety and efficacy data.
Aina Tsuno, Hiroe Kitagaki, Hideki Maeda
wiley   +1 more source

Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta‐Analyses

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6919-6926, August 2026.
ABSTRACT Aims The brain plays a critical role in controlling energy balance. Previous studies have mainly focused on dopaminergic mechanisms, whereas much less attention has been paid to serotonin during the emergence of overweight and obesity. Therefore, this study investigated the association between serotonin transporter (SERT) availability and ...
Kyoungjune Pak
wiley   +1 more source

Decoding Prodromal Lewy Body Disease: Clinical Differences Between Isolated REM Sleep Behavior Disorder and Hyposmia With Dopamine Transporter Deficit

European Journal of Neurology, Volume 33, Issue 8, August 2026.
Isolated REM sleep behavior disorder (iRBD) [n = 360] and hyposmia with dopamine transporter deficit [n = 1101] represent two enriched prodromal Lewy body disease cohorts. Using data from the Parkinson's Progression Markers Initiative, iRBD was associated with significantly greater autonomic symptom burden than hyposmia, driven by constipation and ...
Luke Vikram Banerjee, Jacopo Pasquini, Robin Henderson, Nicola Pavese, Kirstie N. Anderson   +4 more
wiley   +1 more source

Real‐World Outcomes of Radium‐223 Therapy in Metastatic Castration‐Resistant Prostate Cancer: Predictive Value of PSA Doubling Time and Enzalutamide Continuation

International Journal of Urology, Volume 33, Issue 8, August 2026.
ABSTRACT Background Radium‐223 dichloride (Ra‐223) is an effective treatment for metastatic castration‐resistant prostate cancer (mCRPC) with bone metastases. However, predictive factors associated with treatment efficacy remain unclear. This study evaluated prognostic factors associated with the efficacy of Ra‐223 and investigated outcomes according ...
Kodai Abe, Yoshiyuki Miyazawa, Shun Nakazawa, Mai Onose, Yuta Maeno, Yusuke Tsuji, Azusa Kanayama, Akira Ohtsu, Yuji Fujizuka, Seiji Arai, Masashi Nomura, Yoshitaka Sekine, Hidekazu Koike, Hiroshi Matsui, Kazuhiro Suzuki   +14 more
wiley   +1 more source

Quantitative PSMA PET Biomarkers for Predicting Response to ¹⁷⁷Lu-PSMA Therapy in Prostate Cancer: A Systematic Review and Meta-analysis. [PDF]

J Nucl Med
Kiani I, Siri MA, Babaei M, Aliasghari MM, Mohammadzadeh S, Mohammadi S, Salavati A.   +6 more
europepmc   +1 more source

A phase I study to evaluate the dosimetry and safety of [⁸⁹Zr]Zr-DFO-AP-101, a new antibody-based radiopharmaceutical to detect misfolded SOD1 in amyotrophic lateral sclerosis. [PDF]

Eur J Nucl Med Mol Imaging
Croteau E, Rousseau E, Tremblay S, Rousseau JF, Espinosa-Betancourt E, Lavallée E, Dubreuil S, Ait-Mohand S, Lareau-Trudel É, Gosselin S, Carrier V, Côté-Bigras S, Allard C, Maier M, Salzmann M, Tétu A, Houde MP, Turcotte É, Guérin B.   +18 more
europepmc   +1 more source

An international study of factors affecting variability of dosimetry calculations, part 5: impact of segmentation methods. [PDF]

EJNMMI Phys
Kurkowska S, Dewaraja YK, Frey EC, Brosch-Lenz J, Sunderland J, Uribe C.   +5 more
europepmc   +1 more source