Results 1 to 10 of about 63,558 (232)

Microbiome Signatures and Dysbiotic Patterns in Oral Cancer and Precancerous Lesions

Oral Diseases, EarlyView.
ABSTRACT Background The oral microbiome has been shown to be associated with the development of oral squamous cell carcinoma (OSCC). Research has primarily focused on elucidating the oncogenic mechanisms of specific pathogens by comparing the microbiomes of OSCC and normal tissues.
Cheng‐Chieh Yang, Jumpei Washio, Yu‐Cheng Lin, Ming‐Lun Hsu, Ding‐Han Wang, Fa‐Tzu Tsai, Yu‐Min Lin, Hsi‐Feng Tu, Hsiu‐Chuan Chang, Nobuhiro Takahashi   +9 more
wiley   +1 more source

Increasing Prevalence of Syphilis: Oral Manifestations, Diagnosis and Management

Oral Surgery, EarlyView.
ABSTRACT Introduction Cases of syphilis are increasing, with 9513 cases diagnosed in England in 2023, the highest annual number since 1948. Oral healthcare professionals should therefore be aware of how oral syphilis presents, the differential diagnosis and the appropriate care pathway and management.
C. C. Currie, A. Chambers, S. Endersby, R. Green, D. A. Price, N. Robinson, E. Spoor, A. Wilson, M. Robinson   +8 more
wiley   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source

Root surface biomodification in periodontal therapy: Biological rationale and clinical applications

Periodontology 2000, EarlyView.
Abstract Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination
Muhammad H. A. Saleh, Debora R. Dias, Andrea Ravida, Hom‐Lay Wang   +3 more
wiley   +1 more source

The oral microbiota and periodontal health in orthodontic patients

Periodontology 2000, EarlyView.
Abstract The oral microbiota develops within the first 2 years of childhood and becomes distinct from the parents by 4 years‐of‐age. The oral microbiota plays an important role in the overall health/symbiosis of the individual. Deviations from the state of symbiosis leads to dysbiosis and an increased risk of pathogenicity.
Brandon W. Peterson, Geerten‐Has Tjakkes, Anne‐Marie Renkema, David J. Manton, Yijin Ren   +4 more
wiley   +1 more source

Periodontal diseases in Africa

Periodontology 2000, EarlyView.
Abstract Periodontal diseases, a group of complex conditions marked by an excessive immune response and periodontal tissue destruction, are a global health concern. Since 1990, the incidence of these diseases has doubled, with Western sub‐Saharan Africa experiencing the highest burden.
Mojisola Olujitan, Patricia O. Ayanbadejo, Kehinde Umeizudike, Afolabi Oyapero, Christopher Okunseri, Azeez Butali   +5 more
wiley   +1 more source

Characterisation of the Oral Microbiome in Women With Fibromyalgia: An Observational Case–Control Study

European Journal of Pain, Volume 29, Issue 6, July 2025.
ABSTRACT Background Fibromyalgia is a complex disorder, associated with a range of symptoms, not least of which is chronic, widespread pain. Although several reports have brought the role of oral health in systemic diseases into recent focus, the oral microbiome in fibromyalgia is unexplored.
Sharon Erdrich, Thilini Jayasinghe, Momchilo Vuyisich, Ryan Toma, Ingrid Gelissen, Joanna E. Harnett   +5 more
wiley   +1 more source

Inflammation and response to bacterial infection as potential drivers of equine odontoclastic tooth resorption and hypercementosis: A proteomics insight

Equine Veterinary Journal, Volume 57, Issue 4, Page 977-990, July 2025.
Abstract Background Equine dental diseases significantly impact a horse's overall health, performance and quality of life. They can result in secondary infections and digestive disturbances, potentially leading to colic. A recently described disease affecting the incisors of horses is equine odontoclastic tooth resorption and hypercementosis (EOTRH ...
Anders Jensen, Emily J. Clarke, Zoe Nugent, Emily Paice, Iris Gringel, Kazuhiro Yamamoto, Guido Rocchigiani, Andrew J. Peffers, Lee Cooper, Mandy J. Peffers   +9 more
wiley   +1 more source

Prediction Model and Nomogram for Amyloid Positivity Using Clinical and MRI Features in Individuals With Subjective Cognitive Decline

Human Brain Mapping, Volume 46, Issue 8, June 1, 2025.
We established and validated a machine‐learning model and nomogram in individuals with SCD based on cognitive, sMRI, and fMRI data. Our model achieved 83% accuracy to predict Aβ+ in the brain, with an AUC of 88%, sensitivity of 81%, and specificity of 85% in the test set.
Qinjie Li, Liang Cui, Yihui Guan, Yuehua Li, Fang Xie, Qihao Guo   +5 more
wiley   +1 more source

Intradiscal Mesenchymal Stromal Cell Therapy for the Treatment of Low Back Pain Due to Moderate‐to‐Advanced Multilevel Disc Degeneration: A Preliminary Report of a Double‐Blind, Phase IIB Randomized Clinical Trial (DREAM Study)

JOR SPINE, Volume 8, Issue 2, June 2025.
This phase IIB randomized controlled trial evaluated the safety and efficacy of intradiscal injections of autologous bone marrow‐derived mesenchymal stromal cells (BM‐MSCs) in patients with chronic low back pain from moderate‐to‐advanced multilevel disc degeneration.
Gianluca Vadalà, Fabrizio Russo, Cristiana Lavazza, Giorgia Petrucci, Luca Ambrosio, Silvia Budelli, Elisa Montelatici, Giuseppina Di Giacomo, Claudia Cicione, Veronica Tilotta, Giuseppe Francesco Papalia, Matteo Pileri, Amalia Bruno, Salvatore La Rosa, Emilio Carrino, Eliodoro Faiella, Massimiliano Carassiti, Lorenza Lazzari, Rocco Papalia, Vincenzo Denaro   +19 more
wiley   +1 more source