Localization and pathogenic role of the cysteine protease dentipain in Treponema denticola [PDF]
Molecular Oral Microbiology, 2023 The Msp protein complex and the serine protease dentilisin are the best-characterized virulence factors in Treponema denticola, the major etiological agent of chronic periodontitis.
Kazuko Okamoto-Shibayama +2 more
exaly +3 more sources
Glutathione catabolism by Treponema denticola impacts its pathogenic potential [PDF]
Anaerobe, 2020 Treponema denticola is a spirochete that is etiologic for periodontal diseases. This bacterium is one of two periodontal pathogens that have been shown to have a complete three step enzymatic pathway (GTSP) that catabolizes glutathione to H2S.
David Kolodrubetz
exaly +3 more sources
Advances in Treponema denticola and oral diseases
口腔疾病防治, 2020 Treponema denticola is an important pathogenic Treponema pathogen in the human oral cavity. Early studies have found that Treponema denticola is closely related to the occurrence and development of periodontal diseases.
PENG Ruiting, CHENG Lei, PENG Xian
doaj +2 more sources
Purification of Native Dentilisin Complex from Treponema denticola by Preparative Continuous Polyacrylamide Gel Electrophoresis and Functional Analysis by Gelatin Zymography [PDF]
Bio-ProtocolPeriodontal disease is characterized by the destruction of the hard and soft tissues comprising the periodontium. This destruction translates to a degradation of the extracellular matrices (ECM), mediated by bacterial proteases, host-derived matrix ...
Pachiyappan Kamarajan +8 more
doaj +2 more sources
Structure and Mechanism of Ergothionase from Treponema denticola [PDF]
Chemistry – A European Journal, 2019 AbstractErgothioneine is a sulfur‐containing histidine derivative that emerges from microbial biosynthesis and enters the human body through intestinal uptake and regulated distribution into specific tissues. Although the proteins involved in biosynthesis and uptake are well characterized, less is known about the degradative pathways of ergothioneine ...
Alice Maurer +3 more
openaire +5 more sources
Treponema denticola Has the Potential to Cause Neurodegeneration in the Midbrain via the Periodontal Route of Infection-Narrative Review. [PDF]
Int J Environ Res Public Health, 2023 Alzheimer’s disease (AD) is a neurodegenerative disease and the most common example of dementia. The neuropathological features of AD are the abnormal deposition of extracellular amyloid-β (Aβ) and intraneuronal neurofibrillary tangles with ...
Pisani F +4 more
europepmc +2 more sources
Characterization of the Treponema denticola Virulence Factor Dentilisin [PDF]
Methods in molecular biology, 2020 Treponema denticola is a potent periodontal pathogen that forms a red complex with Porphyromonas gingivalis and Tannerella forsythia. It has many virulence factors, yet there are only a few reports detailing these factors. Among them, dentilisin is a well-documented surface protease.
Kikuchi, Y, Ishihara, K
openaire +4 more sources
The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer's Disease Pathology. [PDF]
Int J Environ Res Public Health, 2022 Alzheimer’s Disease (AD) is a complex neurodegenerative disease and remains the most common form of dementia. The pathological features include amyloid (Aβ) accumulation, neurofibrillary tangles (NFTs), neural and synaptic loss, microglial cell ...
Pisani F +4 more
europepmc +2 more sources
Enhanced transformation efficiency in Treponema denticola enabled by SyngenicDNA-based plasmids lacking restriction-modification target motifs. [PDF]
Mol Oral Microbiol, 2023 Oral spirochetes are among a small group of keystone pathogens contributing to dysregulation of tissue homeostatic processes that leads to breakdown of the tissue and bone supporting the teeth in periodontal disease.
Johnston CD +6 more
europepmc +2 more sources
Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis. [PDF]
Int J Mol Sci, 2023 miRNAs are major regulators of eukaryotic gene expression and host immunity, and play an important role in the inflammation-mediated pathways in periodontal disease (PD) pathogenesis.
Aravindraja C +5 more
europepmc +2 more sources