Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola [PDF]
Journal of Oral Microbiology, 2020 Background Porphyromonas gingivalis and Treponema denticola are proteolytic periodontopathogens that co-localize in polymicrobial subgingival plaque biofilms, display in vitro growth symbiosis and synergistic virulence in animal models of disease. These
Lin Xin Kin +2 more
exaly +3 more sources
Diversity of Treponema denticola and Other Oral Treponeme Lineages in Subjects with Periodontitis and Gingivitis [PDF]
Microbiology Spectrum, 2021 More than 75 species/species-level phylotypes belonging to the genus Treponema inhabit the human oral cavity. Treponema denticola is commonly associated with periodontal disease, but the etiological roles and ecological distributions of other oral ...
Huihui Zeng +4 more
doaj +2 more sources
Treponema denticola interactions with host proteins [PDF]
Journal of Oral Microbiology, 2012 Oral Treponema species, most notably T. denticola, are implicated in the destructive effects of human periodontal disease. Progress in the molecular analysis of interactions between T.
J. Christopher Fenno
doaj +4 more sources
Treponema denticola-Induced RASA4 Upregulation Mediates Cytoskeletal Dysfunction and MMP-2 Activity in Periodontal Fibroblasts [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 The periodontal complex consists of the periodontal ligament (PDL), alveolar bone, and cementum, which work together to turn mechanical load into biological responses that are responsible for maintaining a homeostatic environment.
Erin Trent Malone +10 more
doaj +2 more sources
Treponema denticola as a prognostic biomarker for periodontitis in dogs. [PDF]
PLoS One, 2022 Periodontal disease is one of the most common disorders in the oral cavity of dogs and humans. Periodontitis, the irreversible periodontal disease, arises progressively from gingivitis, the reversible inflammatory condition caused by dental plaque. Although the etiology of periodontitis has been widely studied in humans, it is still insufficient for ...
Kwon D +5 more
europepmc +6 more sources
Treponema denticola Induces Neuronal Apoptosis by Promoting Amyloid-β Accumulation in Mice [PDF]
Pathogens, 2022 Background: Neuronal apoptosis is a major contributor to Alzheimer’s disease (AD). Periodontitis is a significant risk factor for AD. The periodontal pathogens Porphyromonas gingivalis and Treponema denticola have been shown to initiate the hallmark ...
Linrui Wu +6 more
doaj +2 more sources
Characterization of clustered bacteriocin-type signal domain protein genes in Treponema denticola [PDF]
Frontiers in Dental MedicineBackgroundPeriodontitis is caused by the dysbiosis of subgingival plaque, and Treponema denticola is the pathogen associated with this disease. Bacteriocins are involved in interbacterial competition during dysbiosis.
Tomoyuki Nukaga +6 more
doaj +2 more sources
Binding properties of Treponema denticola lipooligosaccharide
Journal of Oral Microbiology, 2013 Background and objective: The cell-surface lipooligosaccharide (LOS) of Treponema denticola possesses several biological properties. The aim of this study was to investigate the binding properties of T.
Daniel Grenier
doaj +4 more sources
Genetic Manipulations of Oral Spirochete Treponema denticola. [PDF]
Methods Mol Biol, 2021 There have been more than 60 different oral Treponema species identified in the oral cavity; however, only few species can be cultivated in vitro reliably. Among those cultivable species, due to its medical importance and genetic tractability, Treponema denticola, one of the keystone pathogens associated with human periodontitis, has emerged as a ...
Kurniyati K, Li C.
europepmc +4 more sources
Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis [PDF]
Journal of Oral Microbiology, 2014 Treponema denticola is an important periodontal pathogen capable of tissue invasion. Its chymotrypsin-like proteinase (CTLP) can degrade a number of basement membrane components in vitro, thus suggesting a contribution to tissue invasion by the ...
Emilia Marttila +7 more
doaj +2 more sources