Red-complex bacteria: immunological background leading to the development of head and neck cancers [PDF]
Frontiers in ImmunologyOral microbiome imbalance is involved in the development of head and neck cancers (HNCs). There is a group of oral pathogens, such as Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, that creates red-complex.
Karolina Kaźmierczak-Siedlecka +9 more
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Characterization of Treponema denticola Major Surface Protein (Msp) by Deletion Analysis and Advanced Molecular Modeling. [PDF]
J Bacteriol, 2022 The Treponema denticola gene encoding its major surface protein (Msp) is an ortholog of the T. pallidum tprA to -K gene family that includes tprK, whose remarkable in vivo hypervariability is proposed to contribute to T. pallidum immune evasion.
Goetting-Minesky MP +3 more
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Treponema denticola enolase contributes to the production of antibodies against ENO1 but not to the progression of periodontitis [PDF]
Virulence, 2018 Autoantibodies against alpha-enolase (ENO1) are often detected in various infectious and autoimmune diseases. Anti-ENO1 antibody titers were reported to be associated with the severity of periodontitis in patients with rheumatoid arthritis.
Ahreum Lee +10 more
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Evaluation of Antimicrobial Susceptibility and Resistance Patterns of Treponema denticola Isolated From Periodontal Disease: An In Vitro Study. [PDF]
CureusBackground Periodontal disease poses a significant oral health challenge, involving inflammatory conditions impacting tooth-supporting structures. Treponema denticola, a "red complex" organism, plays a crucial role in periodontal pathogenesis, forming ...
Pawar AR, Ramamurthy J, Girija ASS.
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Treponema denticola Induces Interleukin-36γ Expression in Human Oral Gingival Keratinocytes via the Parallel Activation of NF-κB and Mitogen-Activated Protein Kinase Pathways. [PDF]
Infect Immun, 2022 The oral epithelial barrier acts as both a physical barrier to the abundant oral microbiome and a sentry for the immune system that, in health, constrains the accumulation of the polymicrobial plaque biofilm. The immune homeostasis during gingivitis that
Hinson AN +7 more
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Contemporary Clinical Dentistry, 2016 Background: The detection frequency of Porphyromonas gingivalis and Treponema denticola in chronic periodontitis (CP) and aggressive periodontitis (AgP) is not explored well in Indian population. Aim: The study was undertaken to detect P.
Ramniwas M Kumawat +4 more
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Detection of Periodontal Pathogens from Dental Plaques of Dogs with and without Periodontal Disease
Pathogens, 2022 Dental plaque bacteria are one of the main factors responsible for the development of a periodontal disease, which is the most common infectious disease in dogs.
Jana Kačírová +8 more
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Arginine catabolism by Treponema denticola [PDF]
Journal of Bacteriology, 1976 Treponema denticola, an anaerobe commonly present in the human mouth, ferments various amino acids and glucose. Amino acid analyses indicated that substrate amounts of arginine were utilized by T. denticola growing in a complex, serum-containing medium.
R P, Blakemore, E, Canale-Parola
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Roles of TroA and TroR in Metalloregulated Growth and Gene Expression in Treponema denticola. [PDF]
J Bacteriol, 2020 Treponema denticola is one of numerous host-associated spirochetes, a group including commensals, pathobionts, and at least one frank pathogen. While most T.
Saraithong P +5 more
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Effect of fluoride on Treponema denticola [PDF]
Infection and Immunity, 1986 The effect of fluoride on the growth of Treponema denticola was studied. Fluoride, at a concentration of 20 micrograms/ml, was found to suppress the growth of all three strains tested. Growth was completely inhibited by 40 micrograms of fluoride per ml.
C A, Hughes, W W, Yotis
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