Results 81 to 90 of about 46,044 (219)

Sexually Transmitted Infection Prevalence and Determinants Among Sexual Health Clinic Attendees in Bucharest, Romania

International Journal of Dermatology, EarlyView.
Cross‐sectional study among 70 sexual health clinic attendees (70% MSM) in Bucharest combining multisite STI testing with knowledge, attitudes, and practices assessment. Key findings include 35.5% bacterial STI prevalence, essential extragenital testing, and cost barriers to screening uptake.
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

In Vitro Susceptibility of Treponema pallidum subsp. pallidum to Doxycycline

Antimicrobial Agents and Chemotherapy, 2020
Doxycycline is regarded as an effective therapy for early syphilis, and there is increasing interest in using doxycycline for prophylaxis of this infection. However, the MIC of doxycycline for Treponema pallidum subsp.
D. Edmondson, G. Wormser, S. Norris
semanticscholar   +1 more source

Nodular Secondary Syphilis: Systematic Review of an Underrecognized Clinical Phenotype

International Journal of Dermatology, EarlyView.
Nodular secondary syphilis is a rare and often misdiagnosed manifestation of secondary syphilis with diverse clinical and histopathologic features. This systematic review of 144 cases highlights its frequent association with ulceration, generalized skin involvement, and HIV infection, emphasizing the importance of considering syphilis in the ...
Jacopo Tartaglia, Monica Ponzano, Alvise Sernicola, Roberto Mazzetto, Mauro Alaibac   +4 more
wiley   +1 more source

Is There a Resistance Threshold for Macrolide Consumption? Positive Evidence from an Ecological Analysis of Resistance Data from Streptococcus pneumoniae, Treponema pallidum, and Mycoplasma genitalium

medRxiv, 2020
If we were to keep macrolide consumption below a certain threshold, would this reduce the probability of macrolide resistance emerging? No study that we are aware of has addressed this question.
C. Kenyon, S. Manoharan-Basil, C. Van Dijck   +2 more
semanticscholar   +1 more source

Ulceronecrotic Plaques, Patchy Scalp Alopecia and Visual Disturbance in a 46‐Year‐Old Man

International Journal of Dermatology, EarlyView.
ABSTRACT A 46‐year‐old incarcerated man with chronic hepatitis C infection and intravenous drug use presented with a rapidly progressive pruritic eruption involving the scalp, trunk, and limbs, accompanied by patchy scalp alopecia and bilateral panuveitis.
Alex Majri, Austen Anderson, Jeremy Ng, Nima Mesbah‐Ardakani   +3 more
wiley   +1 more source

Recombinant Treponema pallidum protein Tp0768 promotes proinflammatory cytokine secretion of macrophages through ER stress and ROS/NF-κB pathway

Applied Microbiology and Biotechnology, 2020
In response to danger signals, macrophages rapidly produce many inflammatory cytokines that trigger the cascade release of inflammatory mediators, leading to tissue damage, which is an important cause of clinical manifestations of syphilis at all stages.
Wei Li, Xiangping Zhou, Jialun Cai, Feijun Zhao, Ting Cao, Lichang Ning, Chunyi Luo, Xinhua Xiao, Shuangquan Liu   +8 more
semanticscholar   +1 more source

Treponema pallidum Protein Tp0136 Induces Spheroidization of Vascular Endothelial Cells, Resulting in Widened Intercellular Junctions and Enhanced Vascular Permeability

Small Science
The Treponema pallidum membrane protein Tp0136 facilitates Treponema pallidum dissemination, and the permeability of vasculature is intricately linked to the density of the vascular endothelial barrier, which is strongly associated with the morphology of
Yu Lin, Xi Luo, Xu Shen, Xiao‐Lin Fu, Li‐Rong Lin, Tian‐Ci Yang   +5 more
doaj   +1 more source

Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751

Msphere, 2020
Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum subsp. pallidum. The continued incidence of syphilis demonstrates that screening and treatment strategies are not sufficient to curb this infectious ...
K. Lithgow, Brigette Church, Alloysius Gomez, E. Tsao, S. Houston, L. A. Swayne, C. Cameron   +6 more
semanticscholar   +1 more source

Chronic Ulcer on the Vulva

JEADV Clinical Practice, EarlyView.
Farhanaz Panjshiri, Reed Gioe, Carole Bitar   +2 more
wiley   +1 more source

Donor Dilemma: A National Simulation‐Based Case Curriculum for Teaching Donor Call Decision‐Making in Infectious Diseases Trainees

Transplant Infectious Disease, EarlyView.
An asynchronous donor‐call case‐based progressive disclosure curriculum was feasible and valued across diverse ID and TID training programs. ID and TID trainees reported improved confidence in their clinical reasoning and ability to evaluate donor‐suitability, supporting this educational approach to address a training gap.
Robert Sean Tyler, Rachel B. Colven, Alexandra G. Mills, Drew W. Charles, Ruth O. Adekunle, Divisha Sharma, Yosra Alkabab, Scott R. Curry, Ricardo M. La Hoz, Courtney E. Harris   +9 more
wiley   +1 more source