Results 11 to 20 of about 2,492 (156)

Genomic Insights Into the Treponema Genus: Taxonomic Resolution of Treponema vincentii and Description of Two Novel Species, Treponema plautii sp. nov. and Treponema sinense sp. nov. [PDF]

Mol Oral Microbiol
ABSTRACT Objectives Periodontal disease, a global health concern, is strongly associated with oral treponemes. However, the taxonomy of some species remains unresolved, hindering our understanding of their roles in disease. This study aims to clarify the taxonomy of three strains isolated from patients with periodontal disease using phylogenomic and ...
Fong JYH, Yeung ML, Li TT, Li WH, Ma Y, Zhao Y, Leung WK, Teng JLL.   +7 more
europepmc   +2 more sources

Bright New Resources for Syphilis Research: Genetically Encoded Fluorescent Tags for Treponema pallidum and Sf1Ep Cells. [PDF]

Mol Microbiol
By employing genetic engineering, Treponema pallidum was modified to express GFP, and Sf1Ep cells to express mCherry on the cytoplasmic membrane and BFP in the nucleus. These new resources for syphilis research will facilitate experimental designs to better define the complex interplay between T. pallidum and the host during infection.
Grillová L, Romeis E, Lieberman NAP, Tantalo LC, Xu LH, Molini B, Trejos AT, Lacey G, Goulding D, Thomson NR, Greninger AL, Giacani L.   +11 more
europepmc   +2 more sources

Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms.

PLoS Pathogens, 2021
Here, we report the first complete genomes of three cultivable treponeme species from bovine digital dermatitis (DD) skin lesions, two comparative human treponemes, considered indistinguishable from bovine DD species, and a bovine gastrointestinal (GI ...
Gareth J Staton, Simon R Clegg, Stuart Ainsworth, Stuart Armstrong, Stuart D Carter, Alan D Radford, Alistair Darby, Jonathan Wastling, Neil Hall, Nicholas J Evans   +9 more
doaj   +1 more source

“Non-healing” claw horn lesions in dairy cows: Clinical, histopathological and molecular biological characterization of four cases

Frontiers in Veterinary Science, 2022
The increasing prevalence of bovine digital dermatitis (BDD) contributes to a higher occurrence of secondary infections of exposed corium with Treponema spp. in bovine claws. “Non-healing” claw horn lesions (NHL) clinically resemble BDD lesions. They are
Maher Alsaaod, Jim Weber, Tim Jensen, Tim Jensen, Sabine Brandt, Corinne Gurtner, David Devaux, David Devaux, Eveline Studer, Adrian Steiner   +9 more
doaj   +1 more source

Farm-level risk factors for digital dermatitis in dairy cows in mountainous regions

Journal of Dairy Science, 2023
: Reduction of risk factors for bovine digital dermatitis (BDD) is crucial in current disease control. However, risk factors that might arise especially in mountainous regions are unknown until now, and an adapted BDD control program is consequently ...
Jim Weber, Jens Becker, Claudia Syring, Maria Welham Ruiters, Iwan Locher, Magdalena Bayer, Gertraud Schüpbach-Regula, Adrian Steiner   +7 more
doaj   +1 more source

The occurrence of Treponema spp. in gingival plaque from dogs with varying degree of periodontal disease. [PDF]

PLoS ONE, 2018
Periodontal disease is common in dogs and is initiated by gingival plaque composed of several hundred bacterial species. Some of these species have specifically been pointed out as potential periodontal pathogens, such as Treponema spp.
Janna Nises, Anna Rosander, Ann Pettersson, Annette Backhans   +3 more
doaj   +1 more source

Diversity of Treponema denticola and Other Oral Treponeme Lineages in Subjects with Periodontitis and Gingivitis

Microbiology Spectrum, 2021
More than 75 species/species-level phylotypes belonging to the genus Treponema inhabit the human oral cavity. Treponema denticola is commonly associated with periodontal disease, but the etiological roles and ecological distributions of other oral ...
Huihui Zeng, Yuki Chan, Wenling Gao, W. Keung Leung, Rory M. Watt   +4 more
doaj   +1 more source

Endemic treponemal diseases [PDF]

Transactions of The Royal Society of Tropical Medicine and Hygiene, 2014
The endemic treponemal diseases, consisting of yaws, bejel (endemic syphilis) and pinta, are non-venereal infections closely related to syphilis, and are recognized by WHO as neglected tropical diseases (NTDs). Despite previous worldwide eradication efforts the prevalence of yaws has rebounded in recent years and the disease is now a major public ...
Marks, Michael, Solomon, Anthony W, Mabey, David C   +2 more
openaire   +5 more sources

MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis. [PDF]

PLoS ONE, 2013
Research on syphilis, a sexually transmitted infection caused by the non-cultivatable spirochete Treponema pallidum, has been hampered by the lack of an inbred animal model.
Adam C Silver, Dana W Dunne, Caroline J Zeiss, Linda K Bockenstedt, Justin D Radolf, Juan C Salazar, Erol Fikrig   +6 more
doaj   +1 more source

Infectious disease in the Pleistocene: Old friends or old foes?

American Journal of Biological Anthropology, Volume 182, Issue 4, Page 513-531, December 2023., 2023
Sources of evidence for studying infectious diseases of humans and other Pleistocene hominins. From top to bottom: DNA analysis of humans and hominins, modern and ancient, including the analysis of genomes at a population scale; palaeopathology, such as osteolytic skeletal lesions resulting from infection, and the study of mummified tissues or palaeo ...
Charlotte J. Houldcroft, Simon Underdown
wiley   +1 more source