The FASEB Journal, Volume 39, Issue 15, 15 August 2025.GDF15 and FGF21: Endogenous vs. pharmacological effects on body weight in mice. ABSTRACT GDF15 and FGF21 are stress‐induced hormone‐like factors with putative roles in the regulation of energy homeostasis. Since their plasma levels increase with obesity, it has been proposed that GDF15 and FGF21 jointly impose a cap on weight gain during diet‐induced ...
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