Results 11 to 20 of about 11,188,116 (297)

Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience [PDF]

Trials, 2012
Background Surgeons in the Netherlands, Canada and the US participate in the FAITH trial (Fixation using Alternative Implants for the Treatment of Hip fractures).
Zielinski Stephanie M, Viveiros Helena, Heetveld Martin J, Swiontkowski Marc F, Bhandari Mohit, Patka Peter, Van Lieshout Esther MM   +6 more
doaj   +4 more sources

The CRASH trial protocol (Corticosteroid randomisation after significant head injury) [ISRCTN74459797]. [PDF]

, 2001
BACKGROUND: Worldwide, millions of people are treated each year for significant head injury. A substantial proportion die, and many more are disabled.
The CRASH trial collaborators, The CRASH trial management group, null null   +2 more
core   +2 more sources

UK back pain exercise and manipulation (UK BEAM) trial - national randomised trial of physical treatments for back pain in primary care: objectives, design and interventions [PDF]

, 2003
Low back pain has major health and social implications. Although there have been many randomised controlled trials of manipulation and exercise for the management of low back pain, the role of these two treatments in its routine management remains ...
null null, UK Beam (Back pain Exercise and Manipulation) Trial Team, Burton, A. Kim   +2 more
core   +2 more sources

Primary care practice-based care management for chronically ill patients (PraCMan): study protocol for a cluster randomized controlled trial [ISRCTN56104508] [PDF]

, 2011
Background: Care management programmes are an effective approach to care for high risk patients with complex care needs resulting from multiple co-occurring medical and non-medical conditions.
Baldauf Annika, Gerlach, Ferdinand M., Joachim Szecsenyi, Beyer Martin, Szecsenyi, Joachim, Gerlach Ferdinand M, Peters-Klimm Frank, Ferdinand M Gerlach, Peters-Klimm, Frank, Erler, Antje, Cornelia Mahler, Rochon Justine, Gensichen Jochen, Mahler Cornelia, Freund, Tobias, Martin Beyer, Antje Erler, Szecsenyi Joachim, Gensichen, Jochen, Freund Tobias, Beyer, Martin, Justine Rochon, Mahler, Cornelia, Baldauf, Annika, Tobias Freund, Frank Peters-Klimm, Jochen Gensichen, Rochon, Justine, Erler Antje, Annika Baldauf   +29 more
core   +2 more sources

Evaluation of the clinical and cost effectiveness of intermediate care clinics for diabetes (ICCD) : a multicentre cluster randomised controlled trial [PDF]

, 2014
Background: Configuring high quality care for the rapidly increasing number of people with type 2 diabetes (T2D) is a major challenge worldwide for both providers and commissioners.
Joseph Paul O’Hare, P. Saravanan (2679490), Saravanan, Ponnusamy, Baines Darrin, Khunti, Kamlesh, Andrew Wilson, Hardy, Ainsley, Joseph Paul O’Hare (552525), Ala Szczepura (83137), Darrin Baines (552528), Saravanan Ponnusamy, Sudhesh Kumar (89490), O’Hare Joseph Paul, Ric Crossman (552527), Andrew Wilson (23322), Khunti Kamlesh, Kamlesh Khunti, Hardy, Ainslea, Wilson Andrew, Hardy Ainsley, Crossman, Richard, Ala Szczepura, ICCD trial group (7628486), Wilson, Andrew, Crossman Ric, A. Szczepura (7628477), ICCD trial group, Darrin Baines, Ponnusamy Saravanan (552529), Raymond Neil, Raymond, Neil T., J. P. O'Hare (7628471), N. Raymond (7628474), Baines, Darrin L., Ainsley Hardy, Ainsley Hardy (552526), Kumar Sudhesh, Sudhesh Kumar, Baines, Darrin, Joseph Paul O'Hare, Neil Raymond, Neil Raymond (438247), Szczepura, Ala, Crossman, Ric, Kumar, Sudhesh, Kamlesh Khunti (171607), S. Kumar (746162), Raymond, Neil, Szczepura Ala, D. Baines (7628483), R. Crossman (7628480), O’Hare, Joseph Paul, O'Hare, J. Paul, Ric Crossman, Ponnusamy Saravanan   +54 more
core   +1 more source

Topical steroid versus placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving chemoradiotherapy: the study protocol of J-SUPPORT 1602 (TOPICS study), a randomized double-blinded phase 3 trial

BMC Cancer, 2018
Background To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50–60 Gy irradiation in breast cancer.
Sadamoto Zenda, Takuhiro Yamaguchi, Tomoya Yokota, Tempei Miyaji, Tomoe Mashiko, Mari Tanaka, Masahito Yonemura, Misaki Takeno, Tomoka Okano, Toshikatsu Kawasaki, Yuko Nakamori, Shinobu Ishii, Sanae Shimada, Miyuki Kanamaru, Yosuke Uchitomi   +14 more
doaj   +1 more source

Conservative management versus open reduction and internal fixation for mid-shaft clavicle fractures in adults - The Clavicle Trial: Study protocol for a multicentre randomized controlled trial [PDF]

, 2011
Background: Clavicle fractures account for around 4% of all fractures and up to 44% of fractures of the shoulder girdle. Fractures of the middle third (or mid-shaft) account for approximately 80% of all clavicle fractures.
Cobiella Carlos, Francis, A, Lee, M, Umile Giuseppe Longo, Andrea Francis, Drew, S, Tennent Duncan, Steven Corbett, Packham, I, Pearse, Y, Longo, UG, Nicholas Garlick, Philip Michael Ahrens, Crowther, Mark, Richards, Andrew, Tennent, Duncan, Tims Emily, Tims, E, Richards, A, Pearse, Yemi, Francis Andrea, Garlick, Nicholas, Garlick Nicholas, Lee Marcus, Corbett Steven, Andrew Richards, Tennent, D, Yemi Pearse, Banerjee Sughran, Emily Tims, Tims, Emily, Cobiella, C, Drew Steven, Crowther Mark, Longo, Umile Giuseppe, Roberts, C, Barber Julie, Barber, Julie, Roberts Chris, Chambler Andrew, Pearse Yemi, Julie Barber, Packham, Iain, Corbett, Steve, Longo Umile, Marcus Lee, Francis, Andrea, Roberts, Chris, Chambler, A, Garlick, N, Carlos Cobiella, Mark Crowther, Ahrens, PM, Sughran Banerjee, Banerjee, S, Chambler, Andrew, Steven Drew, Barber, J, Iain Packham, Chris Roberts, Ahrens Philip, Corbett, S, Lee, Marcus, Packham Iain, Drew, Steven, Cobiella, Carlos, Crowther, M, Duncan Tennent, Richards Andrew, Andrew Chambler, Ahrens, Philip Michael, Banerjee, Sughran   +71 more
core   +2 more sources

Analysis of Suspension of Clinical Trials for Drug Registration in China

Frontiers in Pharmacology, 2021
Suspension is an important risk control measure during clinical trials. We investigated the use of this in China and identified common reasons for suspension by analyzing trends, hold issues, outcomes, background and design characteristics of suspended ...
Xian Su, Xian Su, Xiaocong Pang, Xin Zeng, Yi Gao, Yimin Cui, Haixue Wang   +6 more
doaj   +1 more source

Development of a risk-tailored approach and dashboard for efficient management and monitoring of investigator-initiated trials

BMC Medical Research Methodology, 2023
Background Most randomized controlled trials (RCTs) in the academic setting have limited resources for clinical trial management and monitoring. Inefficient conduct of trials was identified as an important source of waste even in well-designed studies ...
Katharina Klatte, Suvitha Subramaniam, Pascal Benkert, Alexandra Schulz, Klaus Ehrlich, Astrid Rösler, Mieke Deschodt, Thomas Fabbro, Christiane Pauli-Magnus, Matthias Briel   +9 more
doaj   +1 more source

Strengthening and stretching for rheumatoid arthritis of the hand (SARAH): design of a randomised controlled trial of a hand and upper limb exercise intervention - ISRCTN89936343 [PDF]

, 2012
Background: Rheumatoid Arthritis (RA) commonly affects the hands and wrists with inflammation, deformity, pain, weakness and restricted mobility leading to reduced function.
Toye, Francine, Lamb, S. E. (Sallie E.), Williamson Esther M, Adams, Jo, Nichols, Vivien P., Heine Peter, McConkey Christopher, Mark A Williams, Nicols, Vivien, Underwood, Martin, Bridle, Christopher, Bridle, C, Lord, J, Bridle, Chris, Esther M Williamson, Joanne Lord, Heine, Peter, Williamson, Esther, Christopher McConkey, Williams, MA, Lamb, Sarah, null null, Heine, Peter J., Dosanjh Sukhdeep, Adams Jo, Francine Toye, Lamb Sarah E, Williams, Mark A., Sukhdeep Dosanjh, Lamb, SE, Chris Bridle, McConkey, Christopher C., Toye, F, Nichols Vivien, Heine, P, Underwood Martin R, Toye Francine, HASH(0x55a6805dc180), Bridle Chris, Williamson, EM, Martin R Underwood, Williams Mark A, Dosanjh, S, Underwood, MR, Jo Adams, Adams, J, Lord, J., McConkey, Christopher, Vivien Nichols, Sarah Trial Team, The, Lord, Joanne, Williams, Mark, Lord Joanne, Dosanjh, Sukhdeep, Nichols, V, Sarah E Lamb, McConkey, C, Peter Heine, Williamson, Esther M.   +58 more
core   +2 more sources