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Database management for clinical trials
Proceedings of the June 13-16, 1977, national computer conference on - AFIPS '77, 1977The Authors describe how they used a standard database management system (System 2000) and a computer utility to build a sophisticated medical records system in support of a national multi-clinic clinical trial. Privacy, protocol adherence, quality control and other key elements of an ethical clinical trial were satisfied at a fraction of the ...
John M. Long, Joseph R. Brashear
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A MANAGEMENT TRIAL FOR DUCHENNE CARDIOMYOPATHY
American Journal of Physical Medicine & Rehabilitation, 1995The physiatrist can now be instrumental in prolonging the survival of individuals with neuromuscular disease by using respiratory muscle aids. As a result, morbidity and mortality from cardiomyopathy are likely to increase for patients with generalized myopathies.
Y, Ishikawa +3 more
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Patient managed clinical trial
Controlled Clinical Trials, 1997We describe a trial design of postmenopausal hormone therapy. Our goal was to design a trial that allows more patient management than usual, would include placebo effect in the therapy, would imitate the normal practices of health care as much as possible, and would be based on ordinary health services.
Hokkanen, T. +7 more
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New England Journal of Medicine, 1949
OBSTETRIC patients usually fall into three broad clinical groups. First, a fairly large number have normal pelvic measurements and satisfactory labor and deliver without difficulty.
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OBSTETRIC patients usually fall into three broad clinical groups. First, a fairly large number have normal pelvic measurements and satisfactory labor and deliver without difficulty.
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A randomized trial of telemedicine for migraine management
Cephalalgia, 2019Objective To determine whether synchronous video-based telemedicine visits with specialists are feasible and to evaluate clinical effectiveness, patient perceptions, and other benefits of telemedicine visits for follow-up migraine care in a tertiary headache center.
Deborah I Friedman +2 more
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Landmark Trials in the Surgical Management of Mesothelioma
Annals of Surgical Oncology, 2021The treatment of mesothelioma has evolved slowly over the last 20 years. While surgery as a standalone treatment has fallen out of favor, the importance of multimodality treatment consisting of combinations of chemotherapy, radiotherapy, and surgery have become more common in operable, fit patients.
Taylor, Kantor, Elliot, Wakeam
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Clinical Trials and Management of Osteochondral Lesions
2018Osteochondral lesions are frequent and important causes of pain and disability. These lesions are induced by traumatic injuries or by diseases that affect both the cartilage surface and the subchondral bone. Due to the limited cartilage ability to regenerate and self-repair, these lesions tend to gradually worsen and progress towards osteoarthritis ...
Carlos A. Vilela +6 more
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Melanoma trials that defined surgical management
Journal of Surgical Oncology, 2021AbstractTreatment of regional lymph nodes in melanoma has been controversial for more than a century. A series of clinical trials evaluating elective lymph node dissection and then sentinel lymph node biopsy have helped define the current standard of care. These trials resulted in increasingly selective application of surgical intervention for regional
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Impact of the SPRINT Trial on Hypertension Management
Annual Review of Medicine, 2018The Systolic Blood Pressure Intervention Trial is the first large prospective randomized controlled trial to demonstrate the benefit of an intensive systolic blood pressure (SBP) treatment target (<120 mm Hg) compared to a standard target (<140 mm Hg) in reducing cardiovascular morbidity and mortality and all-cause mortality in high-risk ...
Lama, Ghazi, Suzanne, Oparil
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A Clinical Trial of Active Management of Labor
Obstetrical & Gynecological Survey, 1995Active management of labor is a multifaceted program that, as implemented at the National Maternity Hospital in Dublin, is associated with a lower rate of cesarean delivery than the rate usually found in the United States. We conducted a randomized trial to evaluate the efficacy of this approach in lowering the rate of cesarean section among women ...
F D, Frigoletto +6 more
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