Results 1 to 10 of about 506,753 (297)

Trial sequential analysis: novel approach for meta-analysis [PDF]

Anesthesia and Pain Medicine, 2021
Systematic reviews and meta-analyses rank the highest in the evidence hierarchy. However, they still have the risk of spurious results because they include too few studies and participants.
Hyun Kang
doaj   +4 more sources

Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols [PDF]

BMC Medical Research Methodology
Background Trial Sequential Analysis (TSA) is a statistical method to control random errors in systematic reviews with meta-analyses of randomised clinical trials.
Sophie Juul, Christian Gunge Riberholt, Markus Harboe Olsen, Joachim Birch Milan, Sigurlaug Hanna Hafliðadóttir, Jeppe Houmann Svanholm, Elisabeth Buck Pedersen, Charles Chin Han Lew, Mark Aninakwah Asante, Johanne Pereira Ribeiro, Vibeke Wagner, Buddheera W. M. B. Kumburegama, Zheng-Yii Lee, Julie Perrine Schaug, Christina Madsen, Christian Gluud   +15 more
doaj   +2 more sources

The adverse effects associated with semaglutide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis [PDF]

BMC Medicine
Background Semaglutide’s disease-specific weight-reducing effects are well established, but its adverse effects, which may not be disease-specific, have not been systematically assessed. The aim of this review was to assess the adverse effects associated
Christina Dam Bjerregaard Sillassen, Johanne Juul Petersen, Pascal Faltermeier, Delal Yucel, Faiza Siddiqui, Rebecca Kjær Andersen, Leonardo Graever, Jonas Leth Bjerg, Caroline Barkholt Kamp, Johannes Grand, Helena Dominguez, Anne Frølich, Peter Gæde, Christian Gluud, Ole Mathiesen, Janus Christian Jakobsen   +15 more
doaj   +2 more sources

No association between myeloperoxidase gene rs2333227 G>A polymorphism and Alzheimer's disease risk: a meta-analysis and trial sequential analysis [PDF]

Journal of Integrative Neuroscience, 2022
Evidence suggests that there is a close association between myeloperoxidase (MPO) gene rs2333227 G>A polymorphism with Alzheimer’s disease (AD) susceptibility.
Zhi-Cheng Fang, Chen-Chen Mao, Ya-Jun Hu, Gong-Li Yang, Lan Zhou   +4 more
doaj   +1 more source

Major mistakes and errors in the use of Trial Sequential Analysis in systematic reviews or meta-analyses – protocol for a systematic review

Systematic Reviews, 2022
Background Adequately conducted systematic reviews with meta-analyses are considered the highest level of evidence and thus directly defines many clinical guidelines. However, the risks of type I and II errors in meta-analyses are substantial.
Christian Gunge Riberholt, Markus Harboe Olsen, Joachim Birch Milan, Christian Gluud   +3 more
doaj   +1 more source

Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention

BMC Medical Research Methodology, 2020
Background Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to inform the
Ravinder Claire, Christian Gluud, Ivan Berlin, Tim Coleman, Jo Leonardi-Bee   +4 more
doaj   +1 more source

Efficacy and Safety of Remimazolam for Procedural Sedation: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Frontiers in Medicine, 2021
Background: Remimazolam is a new ultrashort-acting benzodiazepine. Remimazolam has been approved for procedural sedation by the US Food and Drug Administration in 2020.
Bo-Jyun Jhuang, Bo-Han Yeh, Yen-Ta Huang, Pei-Chun Lai   +3 more
doaj   +1 more source

Patient's care bundle benefits to prevent stroke associated pneumonia: A meta-analysis with trial sequential analysis

Frontiers in Neurology, 2022
BackgroundPatient's care bundle has been found to have a beneficial effect on refractory diseases, but the preventive effect of this strategy on stroke-associated pneumonia (SAP) remains unclear.
Feng Guo, Qiao Fan, Xiaoli Liu, Donghai Sun   +3 more
doaj   +1 more source

Procalcitonin-guided antibiotic therapy in critically ill adults: a meta-analysis

BMC Infectious Diseases, 2017
Background As a novel biomarker of inflammation, procalcitonin (PCT) has proven useful to guide antibiotic therapy in intensive care unit (ICU). However, there are controversial on mortality.
Tao Zhang, Yan Wang, Qianting Yang, Yalin Dong   +3 more
doaj   +1 more source

Parallel Simulations for Analysing Portfolios of Catastrophic Event Risk [PDF]

, 2012
At the heart of the analytical pipeline of a modern quantitative insurance/reinsurance company is a stochastic simulation technique for portfolio risk analysis and pricing process referred to as Aggregate Analysis.
Bahl, Aman, Baltzer, Oliver, Rau-Chaplin, Andrew, Varghese, Blesson   +3 more
core   +2 more sources