Results 1 to 10 of about 508,966 (153)

Trial Sequential Analysis for dichotomous outcomes – a practical guide for systematic review protocols [PDF]

BMC Medical Research Methodology
Background Trial Sequential Analysis (TSA) is a statistical method to control random errors in systematic reviews with meta-analyses of randomised clinical trials.
Sophie Juul, Christian Gunge Riberholt, Markus Harboe Olsen, Joachim Birch Milan, Sigurlaug Hanna Hafliðadóttir, Jeppe Houmann Svanholm, Elisabeth Buck Pedersen, Charles Chin Han Lew, Mark Aninakwah Asante, Johanne Pereira Ribeiro, Vibeke Wagner, Buddheera W. M. B. Kumburegama, Zheng-Yii Lee, Julie Perrine Schaug, Christina Madsen, Christian Gluud   +15 more
doaj   +2 more sources

Acupuncture for chronic urticaria: a systematic review and meta-analysis with trial sequential analysis [PDF]

Frontiers in Neurology
Background and purposeChronic urticaria (CU) manifests as recurrent skin wheals and itching, considerably impacting patient quality of life. This study aimed to evaluate the efficacy and safety of acupuncture treatment for CU using meta-analysis and ...
Ke-Xin Wu, Ke-Xin Wu, Yan Chen, Peng Tang, Peng Tang, Jin Yao, Jin Yao, Xin-Yue Zhang, Xin-Yue Zhang, Qiong-Nan Bao, Ya-Qin Li, Zi-Wen Chen, Zi-Wen Chen, Wan-Qi Zhong, Wan-Qi Zhong, Man-Ze Xia, Man-Ze Xia, Zheng-Hong Chen, Zi-Han Yin, Zi-Han Yin, Fan-Rong Liang, Fan-Rong Liang   +21 more
doaj   +2 more sources

Trial sequential analysis: novel approach for meta-analysis [PDF]

Anesthesia and Pain Medicine, 2021
Systematic reviews and meta-analyses rank the highest in the evidence hierarchy. However, they still have the risk of spurious results because they include too few studies and participants.
Hyun Kang
doaj   +1 more source

No association between myeloperoxidase gene rs2333227 G>A polymorphism and Alzheimer's disease risk: a meta-analysis and trial sequential analysis [PDF]

Journal of Integrative Neuroscience, 2022
Evidence suggests that there is a close association between myeloperoxidase (MPO) gene rs2333227 G>A polymorphism with Alzheimer’s disease (AD) susceptibility.
Zhi-Cheng Fang, Chen-Chen Mao, Ya-Jun Hu, Gong-Li Yang, Lan Zhou   +4 more
doaj   +1 more source

Major mistakes and errors in the use of Trial Sequential Analysis in systematic reviews or meta-analyses – protocol for a systematic review

Systematic Reviews, 2022
Background Adequately conducted systematic reviews with meta-analyses are considered the highest level of evidence and thus directly defines many clinical guidelines. However, the risks of type I and II errors in meta-analyses are substantial.
Christian Gunge Riberholt, Markus Harboe Olsen, Joachim Birch Milan, Christian Gluud   +3 more
doaj   +1 more source

Using Trial Sequential Analysis for estimating the sample sizes of further trials: example using smoking cessation intervention

BMC Medical Research Methodology, 2020
Background Assessing benefits and harms of health interventions is resource-intensive and often requires feasibility and pilot trials followed by adequately powered randomised clinical trials. Data from feasibility and pilot trials are used to inform the
Ravinder Claire, Christian Gluud, Ivan Berlin, Tim Coleman, Jo Leonardi-Bee   +4 more
doaj   +1 more source

Efficacy and Safety of Remimazolam for Procedural Sedation: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Frontiers in Medicine, 2021
Background: Remimazolam is a new ultrashort-acting benzodiazepine. Remimazolam has been approved for procedural sedation by the US Food and Drug Administration in 2020.
Bo-Jyun Jhuang, Bo-Han Yeh, Yen-Ta Huang, Pei-Chun Lai   +3 more
doaj   +1 more source

Patient's care bundle benefits to prevent stroke associated pneumonia: A meta-analysis with trial sequential analysis

Frontiers in Neurology, 2022
BackgroundPatient's care bundle has been found to have a beneficial effect on refractory diseases, but the preventive effect of this strategy on stroke-associated pneumonia (SAP) remains unclear.
Feng Guo, Qiao Fan, Xiaoli Liu, Donghai Sun   +3 more
doaj   +1 more source

Exploring the Benefits of Adaptive Sequential Designs in Time-to-Event Endpoint Settings [PDF]

, 2010
Sequential analysis is frequently employed to address ethical and financial issues in clinical trials. Sequential analysis may be performed using standard group sequential designs, or, more recently, with adaptive designs that use estimates of treatment ...
Emerson, Sarah C, Emerson, Scott S., Rudser, Kyle   +2 more
core   +2 more sources

Procalcitonin-guided antibiotic therapy in critically ill adults: a meta-analysis

BMC Infectious Diseases, 2017
Background As a novel biomarker of inflammation, procalcitonin (PCT) has proven useful to guide antibiotic therapy in intensive care unit (ICU). However, there are controversial on mortality.
Tao Zhang, Yan Wang, Qianting Yang, Yalin Dong   +3 more
doaj   +1 more source