Results 221 to 230 of about 6,757,255 (356)

Randomized, controlled trials, observational studies, and the hierarchy of research designs.

New England Journal of Medicine, 2000
J. Concato, N. Shah, R. Horwitz
semanticscholar   +1 more source

A multi-environment dataset consisting of official field trials for three major crops in the Nordic countries. [PDF]

Sci Data
Aasen NR, Herrera-Foessel SA, Vandeskog SM, Bengtsson T, Dida MG, Drozdik I, Dalmannsdottir S, Gautason E, Grodek JS, Hilmarsson HS, Högnäsbacka M, Jäck O, Kaseva J, Laine A, Lenkoski A, Lillemo M, Lin M, Lundby AM, Mohammadi S, Møllerhagen PJ, Niskanen M, Ortiz R, Skalshøi M, Þórðardóttir AG, Thorkildsen M, NordBalFoodSec consortium.   +25 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Towards Sustainable Clinical Trials

, 2007
Lilford, Richard, Haines, Andy, Siegfried, Nandi, Darbyshire, Janet, Clarke, Mike, Shakur, Haleema, Burnett, Jill, Roberts, Ian, Ramos, Maria, Wilkinson, Paul   +9 more
core  

A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.

New England Journal of Medicine, 1999
P. C. Hébert, G. Wells, M. Blajchman, John C. Marshall, C. Martin, G. Pagliarello, M. Tweeddale, I. Schweitzer, E. Yetisir   +8 more
semanticscholar   +1 more source

Bias in Meta-Analytic Modeling of Surrogate Endpoints in Cancer Screening Trials. [PDF]

Stat Med
Long JP, Roy A, Irajizad E, Do KA, Shen Y.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Differential reinforcement using matched examples and nonexamples expedites the practice needed to learn concepts. [PDF]

J Exp Anal Behav
Williams CL, Woodard RE, Fowler MR, Franks-Jacobucci BA.   +3 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

From Editor-in-Chief: On current issue, acknowledging the best in 2025, new guidelines and statements

Heart Vessels and Transplantation
Gulmira Kudaiberdieva
doaj   +1 more source