Results 1 to 10 of about 4,605 (177)

Structural studies of crystalline forms of triamterene with carboxylic acid, GRAS and API molecules [PDF]

IUCrJ, 2018
Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative ...
Abida Rehman, Amit Delori, David S. Hughes, William Jones   +3 more
doaj   +4 more sources

Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised controlled study [PDF]

BMJ Open
Introduction Hypertension constitutes the primary health burden of cardiovascular diseases, and the global control of blood pressure (BP) remains insufficient.
Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo   +12 more
doaj   +2 more sources

The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial [PDF]

Trials
Background Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite treatment with at least three or more antihypertensive agents.
Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen   +5 more
doaj   +2 more sources

In Silico Analysis of Triamterene as a Potential Dual Inhibitor of VEGFR-2 and c-Met Receptors [PDF]

Journal of Xenobiotics
The vascular endothelial growth factor receptor 2 (VEGFR2) and the hepatocyte growth factor receptor (C-Met) are critical receptors for signaling pathways controlling crucial cellular processes such as cell growth, angiogenesis and tissue regeneration ...
Stuart Lutimba, Baraya Saleem, Eiman Aleem, Mohammed A. Mansour   +3 more
doaj   +2 more sources

Computer aided greenness by design approach for resolving and quantifying Triamterene and Hydrochlorothiazide in pharmaceutical mixtures employing multiscale dynamics simulations [PDF]

Scientific Reports
In this study, we present an established approach for the UV spectroscopic determination of Hydrochlorothiazide and Triamterene in pharmaceutical mixtures, leveraging the principles of Greenness-by-Design (GbD).
Ahmed Elsonbaty, Khaled Attala, Eman Darweish   +2 more
doaj   +2 more sources

Increase in bile acids after sleeve gastrectomy improves metabolism by activating GPBAR1 to increase cAMP in mice with nonalcoholic fatty liver disease [PDF]

Immunity, Inflammation and Disease
Background Bile acids (BAs) concentration can affect metabolic improvement caused by bariatric surgery and BA concentrations increase in patients after sleeve gastrectomy (SG). Here, how BAs after SG affect metabolism in nonalcoholic fatty liver disease (
Guoliang Li, Xin Xu, Lixin Chai, Qunhao Guo, Wei Wu   +4 more
doaj   +2 more sources

Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats [PDF]

Pharmaceuticals, 2023
Andrographolide (ADG) is contained in bitter plants, and its effects are widely thought to be associated with taste receptors. The current study used animal studies and cell lines to investigate the role of ADG in diabetic models.
Yingxiao Li, Kai-Chun Cheng, I-Min Liu, Juei-Tang Cheng   +3 more
doaj   +2 more sources

Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease [PDF]

Scientific Reports
Parkinson’s disease (PD) is a complex neurodegenerative disorder that affects multiple neurotransmitters, and its exact cause is still unknown. Developing new drugs for PD is a lengthy and expensive process, making it difficult to find new treatments ...
María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez   +6 more
doaj   +2 more sources

In-depth analysis of immune cell landscapes reveals differences between lung adenocarcinoma and lung squamous cell carcinoma [PDF]

Frontiers in Oncology
BackgroundLung cancer is the leading cause of cancer deaths globally, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being major subtypes.
Xinfeng Wang, Keao Zheng, Zhiying Hao
doaj   +2 more sources

Simultaneous Determination of Xipamide and Triamterene by First Derivative, Ratio Difference, and Derivative Ratio Spectrophotometric Methods

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Validated, rapid and sensitive spectrophotometric techniques were established for simultaneous determination of Xipamide and Triamterene. The first technique based on determination of Triamterene with zero-crossing of Xipamide using zero order method at ...
Nermin Victor, Haitham Elfiky, Amr Badawey, Maha Abdelghany   +3 more
doaj   +1 more source