Results 1 to 10 of about 2,405 (150)

Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised controlled study [PDF]

BMJ Open
Introduction Hypertension constitutes the primary health burden of cardiovascular diseases, and the global control of blood pressure (BP) remains insufficient.
Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo   +12 more
doaj   +2 more sources

Liddle Syndrome Presenting as Hypertensive Crisis and Myocardial Injury in a Young Male: A Case Report. [PDF]

Case Rep Nephrol
Introduction Liddle’s syndrome is a rare inherited disorder associated with early‐onset and resistant hypertension due to hyperactivity of epithelial sodium channels (ENaCs). The condition is caused by mutations in the genes SCNN1A, SCNN1B, and SCNN1G. Liddle’s syndrome leads to hypertension, hypokalemia, and metabolic alkalosis.
Khan A, Batool A, Nisar A, Farman J, Tahir O, Javaid MH, Mahato RK, Ali T.   +7 more
europepmc   +2 more sources

The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial [PDF]

Trials
Background Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite treatment with at least three or more antihypertensive agents.
Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen   +5 more
doaj   +2 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease. [PDF]

Adv Sci (Weinh)
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Elia A, Parodi-Rullan R, Vazquez-Torres R, Carey A, Zhao H, Javadov S, Fossati S.   +6 more
europepmc   +2 more sources

In Silico Analysis of Triamterene as a Potential Dual Inhibitor of VEGFR-2 and c-Met Receptors [PDF]

Journal of Xenobiotics
The vascular endothelial growth factor receptor 2 (VEGFR2) and the hepatocyte growth factor receptor (C-Met) are critical receptors for signaling pathways controlling crucial cellular processes such as cell growth, angiogenesis and tissue regeneration ...
Stuart Lutimba, Baraya Saleem, Eiman Aleem, Mohammed A. Mansour   +3 more
doaj   +2 more sources

Computer aided greenness by design approach for resolving and quantifying Triamterene and Hydrochlorothiazide in pharmaceutical mixtures employing multiscale dynamics simulations [PDF]

Scientific Reports
In this study, we present an established approach for the UV spectroscopic determination of Hydrochlorothiazide and Triamterene in pharmaceutical mixtures, leveraging the principles of Greenness-by-Design (GbD).
Ahmed Elsonbaty, Khaled Attala, Eman Darweish   +2 more
doaj   +2 more sources

Large Volume Leukapheresis in a Patient With Meniere's Disease. [PDF]

J Clin Apher
Journal of Clinical Apheresis, Volume 40, Issue 3, June 2025.
Cooling L.
europepmc   +2 more sources

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale. [PDF]

Geriatr Gerontol Int
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Mogi M, Liu S, Suzuki Y, Shibata Y, Yamada S.   +4 more
europepmc   +2 more sources

Increase in bile acids after sleeve gastrectomy improves metabolism by activating GPBAR1 to increase cAMP in mice with nonalcoholic fatty liver disease [PDF]

Immunity, Inflammation and Disease
Background Bile acids (BAs) concentration can affect metabolic improvement caused by bariatric surgery and BA concentrations increase in patients after sleeve gastrectomy (SG). Here, how BAs after SG affect metabolism in nonalcoholic fatty liver disease (
Guoliang Li, Xin Xu, Lixin Chai, Qunhao Guo, Wei Wu   +4 more
doaj   +2 more sources

Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease [PDF]

Scientific Reports
Parkinson’s disease (PD) is a complex neurodegenerative disorder that affects multiple neurotransmitters, and its exact cause is still unknown. Developing new drugs for PD is a lengthy and expensive process, making it difficult to find new treatments ...
María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez   +6 more
doaj   +2 more sources