Results 31 to 40 of about 5,142 (225)
mTORC2 critically regulates renal potassium handling [PDF]
, 2016 The mTOR pathway orchestrates cellular homeostasis. The rapamycin-sensitive mTOR complex (mTORC1) in the kidney has been widely studied; however, mTORC2 function in renal tubules is poorly characterized.
Ahmed, Azaz +14 more
core +1 more source
Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma [PDF]
, 2022 Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete resection is not possible, and chemotherapy and radiotherapy are currently only palliative.
Brat, Daniel J +15 more
core +1 more source
Drug-induced nephrolithiasis and crystalluria: the particular case of the sulfasalazine derivatives
Comptes Rendus. Chimie, 2021 Introduction: Drug-induced calculi are rarely reported in literature but represent a seldom reported complication of long-term or high-dose prescription of certain medications. We review here some drugs involved in stone formation from first case reports
Chebion, Guillaume +4 more
doaj +1 more source
Triamterene bladder calculus [PDF]
Urology, 1987 A case report of triamterene bladder calculus is presented. Triamterene containing antihypertensives should be used with caution in patients with predisposition to form stones.
openaire +4 more sources
NaCl exposure results in increased expression and processing of IL-1β in Meniere’s disease patients
Scientific Reports, 2022 Meniere’s disease (MD) is a chronic disease that causes episodic vertigo, fluctuating hearing loss, and aural fullness, initially managed by dietary salt reduction, and use of diuretics.
Shresh Pathak, Andrea Vambutas
doaj +1 more source
Angewandte Chemie, Volume 136, Issue 51, December 16, 2024.To identify the core region driving tauopathy, tau repeats within the microtubule‐binding domain were synthesized and assessed for pathogenic traits. Repeat 3 initiated amyloid formation, cytotoxicity, and cognitive decline, with oligomeric aggregates showing pronounced neurotoxicity. This pathological form was utilized in a screening platform, leading
Soljee Yoon +8 more
wiley +2 more sources
BMC Nephrology, 2018 Background Liddle’s syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits.
Eriko Yamaguchi +8 more
doaj +1 more source
Ventricular tachycardia associated with lacosamide co-medication in drug-resistant epilepsy. [PDF]
, 2012 We report a case of sustained ventricular tachycardia following the initiation of lacosamide as adjunctive epilepsy treatment. A 49-year-old male with intractable frontal lobe seizures experienced severe ventricular tachycardia following the addition of ...
DeGiorgio, Andrew C +3 more
core +1 more source
Thyroxine-binding globulin: investigation of microheterogeneity [PDF]
, 1981 Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland +4 more
core +1 more source
The infuence of the host microbiome on 3,4- methylenedioxymethamphetamine (MDMA)-induced hyperthermia and vice versa [PDF]
, 2019 Hyperthermia induced by 3,4-methylenedioxymethamphetamine (MDMA) can be life-threatening. Here, we investigate the role of the gut microbiome and TGR5 bile acid receptors in MDMA-mediated hyperthermia.
Bodnar, Sara R +6 more
core +3 more sources