Results 51 to 60 of about 4,579 (198)
Angewandte Chemie, Volume 136, Issue 51, December 16, 2024.To identify the core region driving tauopathy, tau repeats within the microtubule‐binding domain were synthesized and assessed for pathogenic traits. Repeat 3 initiated amyloid formation, cytotoxicity, and cognitive decline, with oligomeric aggregates showing pronounced neurotoxicity. This pathological form was utilized in a screening platform, leading
Soljee Yoon +8 more
wiley +2 more sources
The Journal of Clinical Hypertension, 2021 In a randomized, double‐blind, placebo‐controlled trial, we investigated antihypertensive treatment effect of a quadruple single‐pill combination of reserpine 0.1 mg, dihydralazine 12.5 mg, hydrochlorothiazide 12.5 mg, and triamterene 12.5 mg, and ...
Lei‐Xiao Hu +8 more
doaj +1 more source
Management of hyperkalemia in the acutely ill patient. [PDF]
, 2019 PURPOSE:To review the mechanisms of action, expected efficacy and side effects of strategies to control hyperkalemia in acutely ill patients. METHODS:We searched MEDLINE and EMBASE for relevant papers published in English between Jan 1, 1938, and July 1,
Dépret, François +5 more
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CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.The combined ACD use and elevated NfL levels jointly increased the risk of incident dementia. Older adults with both high ACDs exposure and high NfL levels exhibited a significantly higher risk of dementia compared to low‐burden counterparts. ABSTRACT Aims Anticholinergic drugs (ACDs) and the neurodegeneration biomarker neurofilament light chain (NfL ...
Danyi Chi +6 more
wiley +1 more source
Drug Design, Development and Therapy, 2017 Yingxiao Li,1,2 Kai Chun Cheng,1 Chiang-Shan Niu,3 Shih-Hsiang Lo,3,4 Juei-Tang Cheng,2,5 Ho-Shan Niu31Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; 2Department of ...
Li Y +5 more
doaj
A Case of Recurrent Renal Aluminum Hydroxide Stone
Case Reports in Urology, 2014 Renal stone disease is characterized by the differences depending on the age, gender, and the geographic location of the patients. Seventy-five percent of the renal stone components is the calcium (Ca).
Basri Cakıroglu +4 more
doaj +1 more source
Liddle′s syndrome: A case report
Saudi Journal of Kidney Diseases and Transplantation, 2015 Liddle′s syndrome or pseudoaldosteronism is a rare autosomal dominant disease mimicking primary hyperaldosteronism, characterized by early-onset hypertension, hypokalemia and hypoaldosteronism, caused by excessive salt and water reabsorption in the ...
Pranav Patel, Reena Kuriacose
doaj +1 more source
Effect of diuretics on the plasma lipid profile [PDF]
, 2017 Hypertension, dyslipidaemia, glucose intolerance (associated with insulin resistance and compensatory hyperinsulinaemia) and other abnormalities are complementary coronary risk factors which often occur in association.
de Courten, M. +2 more
core
Personalized medicine—a modern approach for the diagnosis and management of hypertension [PDF]
, 2017 The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage.
Borghi, Claudio +5 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1463-1476, December 2025.Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu +21 more
wiley +1 more source