Results 41 to 50 of about 4,605 (177)

Modelling the impact of atherosclerosis on drug release and distribution from coronary stents [PDF]

open access: yes, 2015
Although drug-eluting stents (DES) are now widely used for the treatment of coronary heart disease, there remains considerable scope for the development of enhanced designs which address some of the limitations of existing devices.
A Neubert   +80 more
core   +2 more sources

The Pharmacology of Newer Diuretics [PDF]

open access: yes, 1967
There are now a number of different classes of diuretics with different pharmacologic effects. Several considerations dictate the choice of diuretic: 1. The responsiveness of the patient is of prime importance. If the patient is not known to be resistant
Wasserman, Albert J.
core   +1 more source

The EuroHeart Failure Survey programme—a survey on the quality of care among patients with heart failure in Europe Part 2: treatment [PDF]

open access: yes, 2003
National surveys suggest that treatment of heart failure in daily practice differs from guidelines and is characterized by underuse of recommended medications.
Aguilar, JC   +17 more
core   +2 more sources

Screening and Diagnosis of Primary Aldosteronism in Patients Using Renin‐Angiotensin System Inhibitors

open access: yesThe Journal of Clinical Hypertension, Volume 28, Issue 1, January 2026.
ABSTRACT This study investigated whether patients receiving renin‐angiotensin system inhibitors (RASIs) can undergo reliable screening for primary aldosteronism (PA) without discontinuation of therapy. Consecutive patients with hypertension who underwent PA screening at our hospital between 2016 and 2024 while on RASIs were recruited.
Qian Wang   +4 more
wiley   +1 more source

Drug Discovery and Screening Tool Development for Tauopathies by Focusing on Pathogenic Tau Repeat 3 Oligomers

open access: yesAngewandte Chemie, Volume 136, Issue 51, December 16, 2024.
To identify the core region driving tauopathy, tau repeats within the microtubule‐binding domain were synthesized and assessed for pathogenic traits. Repeat 3 initiated amyloid formation, cytotoxicity, and cognitive decline, with oligomeric aggregates showing pronounced neurotoxicity. This pathological form was utilized in a screening platform, leading
Soljee Yoon   +8 more
wiley   +2 more sources

Priprava uzoraka i određivanje diuretika u tjelesnim tekućinama čovjeka pomoću RPHPLC [PDF]

open access: yes, 2006
This article described reverse phase high-performance liquid chromatography (RPHPLC) methods for determination of diuretics in different human body fluids (whole blood, plasma, serum or urine).
DRAGICA ZENDELOVSKA, TRAJČE STAFILOV
core   +1 more source

Joint Effects of Anticholinergic Burden and Neurofilament Light on Dementia Risk: The Shanghai Aging Study

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The combined ACD use and elevated NfL levels jointly increased the risk of incident dementia. Older adults with both high ACDs exposure and high NfL levels exhibited a significantly higher risk of dementia compared to low‐burden counterparts. ABSTRACT Aims Anticholinergic drugs (ACDs) and the neurodegeneration biomarker neurofilament light chain (NfL ...
Danyi Chi   +6 more
wiley   +1 more source

Personalized medicine—a modern approach for the diagnosis and management of hypertension [PDF]

open access: yes, 2017
The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage.
Borghi, Claudio   +5 more
core   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1463-1476, December 2025.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu   +21 more
wiley   +1 more source

A Prospective Analysis of Adverse Drug Reactions in a South Indian Hospital [PDF]

open access: yes, 2009
Adverse drug reactions are a great cause of concern to the medical profession, the patients and the pharmaceutical industry. However ADR reporting and monitoring is yet to catch up in India.
Adhikari, P, Padmaja, U, Pereira, P
core   +3 more sources

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