Results 21 to 30 of about 401,052 (253)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman +9 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Translative Covering a Square with Isosceles Right Triangles
GeometryA translative covering the rectangle a×b with homothetic copies of a right isosceles triangle T (of the legs parallel to the sides of a×b) is considered.
Janusz Januszewski, Łukasz Zielonka
doaj +1 more source
Mariangela in Verga’s La caccia al lupo: From Page to Stage
Between, 2013 This article considers the transposition from short story into play of Giovanni Verga’s La caccia al lupo. This pair of texts has been studied less than Cavalleria rusticana and La Lupa,and therefore the present discussion aims to contribute to existing ...
Enza De Francisci
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
La Fausse Suivante, ou la dynamique du triangle [PDF]
Çédille: Revista de Estudios Franceses, 2009 The dramaturgy of Marivaux’s comedy La Fausse Suivante weaves the relationships of its characters into a triangular shape. It isa changing inter-action due to the presence of masks hiding their truth. This system of unstable triangles’ axis is the triple
María Teresa Ramos Gómez
doaj
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
The fractional chromatic number of triangle-free subcubic graphs [PDF]
, 2014 Heckman and Thomas conjectured that the fractional chromatic number of any triangle-free subcubic graph is at most 14 / 5. Improving on estimates of Hatami and Zhu and of Lu and Peng, we prove that the fractional chromatic number of any triangle-free ...
Král’, Daniel +5 more
core +1 more source