Results 31 to 40 of about 1,099,483 (264)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
SensorsSoil–Vegetation–Atmosphere Transfer (SVAT) models are a promising avenue towards gaining a better insight into land surface interactions and Earth’s system dynamics.
George P. Petropoulos, Christina Lekka
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Mariangela in Verga’s La caccia al lupo: From Page to Stage
Between, 2013 This article considers the transposition from short story into play of Giovanni Verga’s La caccia al lupo. This pair of texts has been studied less than Cavalleria rusticana and La Lupa,and therefore the present discussion aims to contribute to existing ...
Enza De Francisci
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, 2014 An (additive) functor F from an additive category A to an additive category B is said to be objective, provided any morphism f in A with F(f) = 0 factors through an object K with F(K) = 0.
Ringel, Claus Michael, Zhang, Pu
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
New Findings in Old Geometry: Using Triangle Centers to Create Similar or Congruent Triangles [PDF]
, 2016 The Euler line of a triangle passes through several important points, including three specific triangle centers: the centroid, orthocenter, and circumcenter.
Capaldi, Mindy B, Lezark, Kathryn E
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
La Fausse Suivante, ou la dynamique du triangle [PDF]
Çédille: Revista de Estudios Franceses, 2009 The dramaturgy of Marivaux’s comedy La Fausse Suivante weaves the relationships of its characters into a triangular shape. It isa changing inter-action due to the presence of masks hiding their truth. This system of unstable triangles’ axis is the triple
María Teresa Ramos Gómez
doaj
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source