Results 171 to 180 of about 80,033 (290)

The fight of innate immunity and abnormal cannabinoids against Candida infection

British Journal of Pharmacology, EarlyView.
Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori, Ilan Zaffran, Francesca Levi Schaffer   +2 more
wiley   +1 more source

Real-World Use of Rezafungin for the Treatment of Challenging Aspergillus Infections. [PDF]

Mycoses
Stone N, Bachiller-Luque P, Giuliano S, Pai S, Pernas B, Garcia-Vidal C, Tyler N, Ferin S, Tascini C, Cruz AF.   +9 more
europepmc   +1 more source

Design, Synthesis and Biophysical Characterisation of CPP-PNA Conjugates for Targeting Oncogenic microRNA-221. [PDF]

J Pept Sci
Rotondo M, Illien F, Burlina F, Biondi B.   +3 more
europepmc   +1 more source

Evolution of Dermatophytic Fungi: Anthropogenic and Biogenic Environmental Factors

International Journal of Dermatology, EarlyView.
ABSTRACT Climate change presents new challenges to dermatologic care, ranging from anthropogenic factors, such as pollution that select for extremotolerant and potentially antifungal‐resistant fungi, to biogenic factors that can drive zoonotic outbreaks, which have received increased attention since the SARS‐CoV‐2 pandemic.
Aditya K. Gupta, Tong Wang, Richard C. Summerbell   +2 more
wiley   +1 more source

Targeting FTSJ1 to Restore TP53 Function in Nonsense Mutation-Driven Cancer: Computational and Experimental Evaluation of 1,2,4-Triazole Derivatives. [PDF]

Molecules
Roomi MS, Culletta G, Lombardo V, Vitale E, Ricci D, Varrica R, Fiduccia I, Pace A, Lentini L, Pibiri I, Tutone M.   +10 more
europepmc   +1 more source

Systemic treatment of cutaneous leishmaniasis: A systematic review and meta‐analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review and meta‐analysis assessed systemic treatments for cutaneous leishmaniasis across 83 studies and 4603 patients. Treatment efficacies of meglumine antimoniate, miltefosine, azoles, pentamidine, and liposomal amphotericin B varied by region and species. Miltefosine showed consistent evidence across multiple settings.
Maximilian Egg, Dennis Wienand, Lucie Harpain, Marie‐Luise Brunner‐Kovarik, Julia Walochnik, Markus Wiesmueller, Amélie Hampel, Tibor Spath, Lukas Trnka, Judit Simon, Alessandra Handisurya   +10 more
wiley   +1 more source

Exploring the Anticancer Potential of Novel Piperidine-Embedded Isoxazol-Triazole Conjugates Against MCF-7 Human Breast Adenocarcinoma Cell Line: Design, Synthesis, In Silico, and In Vitro Investigations. [PDF]

Chem Biodivers
Ghonia JR, Parikh J, Dholakiya BZ.
europepmc   +1 more source

Consensus recommendations for Trichophyton indotineae: A modified Delphi study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A modified Delphi consensus for suspected terbinafine‐resistant T. indotineae: confirm dermatophytes with KOH microscopy/culture and species‐level PCR/ITS sequencing. Itraconazole is recommended as first‐line systemic therapy, with luliconazole 1% cream as a topical adjunct. Posaconazole may be considered if itraconazole fails, while keeping antifungal
Aditya K. Gupta, Mesbah Talukder, Ditte Marie L. Saunte, Roderick James Hay, Michael Arabatzis, Avrom S. Caplan, Eran Galili, Eckart Haneke, Matilde Iorizzo, Riad Kassem, Ananta Khurana, Shari R. Lipner, Anna Lyakhovitsky, Brian W. Morrison, Vincent Piguet, Bianca Maria Piraccini, Carmen Rodríguez‐Cerdeira, Avner Shemer, Michela Starace, Olav Sundnes, Antonella Tosti   +20 more
wiley   +1 more source

<i>Averrhoa bilimbi</i> L. Juice: An efficient natural acid catalyst for the green synthesis of dihydropyrimidinone-1,2,3-triazole. [PDF]

MethodsX
Ardiansah B, Evan J, Jumina, Santoso M, Tanimoto H, Rohman N, Cahyana AH.   +6 more
europepmc   +1 more source

Platelet‐Rich Fibrins as Local Drug‐Delivery Carriers

Journal of Periodontal Research, EarlyView.
Autologous platelet concentrates (APCs), particularly platelet‐rich fibrin (PRF), act as biologically active fibrin scaffolds, capable of entrapping and gradually releasing therapeutic agents in oral and periodontal therapy. The incorporation of bioactive compounds, such as antibiotics, antifungals, vitamins, antidiabetic drugs, and exosomes, enhances ...
Karim M. Fawzy El‐Sayed, Christof E. Dörfer   +1 more
wiley   +1 more source