Results 161 to 170 of about 70,161 (298)

Prevalence of cyp51A variants in a US collection of Aspergillus fumigatus clinical isolates and comparative analysis of their contribution to triazole antifungal resistance. [PDF]

J Antimicrob Chemother
Gómez Londoño LF, Souza ACO, Burt B, Das S, Ge W, Meza-Perez V, Wiederhold NP, Shelat AA, Cuomo CA, Fortwendel JR, Rogers PD.   +10 more
europepmc   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Recent Advances in Benzimidazole-Triazole Hybrids for Single- and Multi-Target Protein Kinase Inhibition. [PDF]

Pharmaceuticals (Basel)
Abu Al Rub HM, Eissa AG.
europepmc   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Impact of Concomitant Metamizole Treatment on the Exposure of Mould-Active Triazoles. [PDF]

Mycoses
Vanneste D, De Booser I, Nadrah K, Somrak M, Gijsen M, Matos A, Kalan K, Morlion B, Rex S, Battelino S, Lagrou K, Maertens J, Spriet I.   +12 more
europepmc   +1 more source

Corrosion‐Protection of T122 Steel Using g‐C3N5‐Embedded Epoxy Coatings

Materials and Corrosion, EarlyView.
Study evaluates g‐C3N5 (CN) reinforced epoxy coatings on T122 steel in NaCl and H2SO4. Electrochemical tests revealed that 2% loading maximizes corrosion resistance by blocking pores and limiting ion diffusion, increasing Rp and Rn. Optimized CN content enhances epoxy coating performance overall system durability material. ABSTRACT Corrosion‐protection
Martha Patricia Hernández‐Valencia, Tathagata Kar, Maura Casales‐Díaz, José Juan Ramos‐Hernández, América María Ramírez‐Arteaga, José Gonzalo González‐Rodríguez, Roy López‐Sesenes, Mohan Kumar Kesarla   +7 more
wiley   +1 more source

Imaging of Fibroblast Activation Protein in the Microenvironment of Tumors by ¹⁸F‑Labeled Positron Emission Tomography Tracers with Increased Polarity. [PDF]

ACS Pharmacol Transl Sci
Köchel R, Wagner S, Breyholz HJ, Schäfers M, Schwegmann K, Wünsch B.   +5 more
europepmc   +1 more source

Multi‐Responsive PAA/PNIPAM Semi‐IPN Hydrogel Properties Controlled by PAA Topology

Macromolecular Rapid Communications, EarlyView.
Polymer topology governs hydrogel behavior in semi‐interpenetrating networks. Cyclic poly(acrylic acid) enables controlled pH‐responsive swelling, improved stability, and enhanced deformability compared to linear analogues, while linear systems show higher strength during thermal de‐swelling.
Suraj Aswale, Gyeong Min Choi, Hyerin Kang, Aruna Kumar Mohanty, Hanyoung Kim, Hong Y. Cho, Heon Sang Lee, Hyun‐jong Paik   +7 more
wiley   +1 more source

Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice. [PDF]

Neuropsychopharmacology
Volf A, Brust TF, Kobylski RR, Czekner KM, Stahl EL, Cameron MD, Trojniak AE, Wood AB, Aubé J, Bohn LM.   +9 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source