Results 101 to 110 of about 2,412 (183)

Transcriptome profiling of Trichoplax adhaerens highlights its digestive epithelium and a rich set of genes for fast electrogenic and slow neuromodulatory cellular signaling

, 2019
Background Trichoplax adhaerens is a fascinating early-diverging animal that lacks a nervous system and synapses, and yet is capable of directed motile feeding behavior culminating in the external digestion of microorganisms by secreted hydrolytic ...
Yuen-Yan Wong, Phuong Le, Wassim Elkhatib, T. Piekut, A. Senatore   +4 more
semanticscholar   +1 more source

Distinct expression patterns of the two T-box homologues Brachyury and Tbx2/3 in the placozoan Trichoplax adhaerens [PDF]

, 2018
Trichoplax adhaerens is the only species known from the phylum Placozoa with one of the simplest metazoan body plans. In the small disc-like organism an upper and a lower epithelium can be distinguished with a less compact third cell layer in between ...
Martinelli, Cosimo, Spring, Jürg
core  

Evolution of selenoproteins in the metazoan

BMC Genomics, 2012
Background The selenocysteine (Sec) containing proteins, selenoproteins, are an important group of proteins present throughout all 3 kingdoms of life.
Jiang Liang, Ni Jiazuan, Liu Qiong
doaj   +1 more source

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue

The Journal of General Physiology, 2017
Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous system, but little is known about when or how their unique properties and cellular roles evolved.
Carolyn L. Smith, S. Abdallah, Yuen-Yan Wong, Phuong Le, Alicia N. Harracksingh, L. Artinian, Arianna N. Tamvacakis, V. Rehder, T. Reese, A. Senatore   +9 more
semanticscholar   +1 more source

apex Mk.2/Mk.3: Secure Live Transmission of the First Flight of Trichoplax adhaerens in Space Based on Components Off-the-Shelf

Eng
After the successful flight of the first Advanced Processors, Encryption, and Security Experiment (apex) Commercial Off-the-Shelf (COTS) On-Board Computer (OBC) during the Propulsion Technologies and Components of Launcher Stages (ATEK)/Material Physics ...
Nico Maas, Jean-Pierre de Vera, Moritz Jonathan Schmidt, Pia Reimann, Jason G. Randall, Sebastian Feles, Ruth Hemmersbach, Bernd Schierwater, Jens Hauslage   +8 more
doaj   +1 more source

The backbone of the post-synaptic density originated in a unicellular ancestor of choanoflagellates and metazoans

BMC Evolutionary Biology, 2010
Background Comparative genomics of the early diverging metazoan lineages and of their unicellular sister-groups opens new window to reconstructing the genetic changes which preceded or accompanied the evolution of multicellular body plans.
Manuel Michaël, Alié Alexandre
doaj   +1 more source

A Tale of Two Drug Targets: The Evolutionary History of BACE1 and BACE2

Frontiers in Genetics, 2013
The beta amyloid (APP) cleaving enzyme (BACE1) has been a drug target for Alzheimer's Disease (AD) since 1999 with lead inhibitors now entering clinical trials.
Christopher eSouthan, John eHancock
doaj   +1 more source

Trichoplax, the simplest known animal, contains an estrogen-related receptor: Implications for the evolution of vertebrate and invertebrate estrogen receptors [PDF]

, 2008
Although, as their names imply, vertebrate and invertebrate estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood.
Michael E. Baker
core  

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

BMC Evolutionary Biology, 2009
Background The question of how genomic processes, such as gene duplication, give rise to co-ordinated organismal properties, such as emergence of new body plans, organs and lifestyles, is of importance in developmental and evolutionary biology.
Moustakas Aristidis, Freilich Shiri, Goldovsky Leon, Huminiecki Lukasz, Ouzounis Christos, Heldin Carl-Henrik   +5 more
doaj   +1 more source

Conservation of DNA and Ligand Binding Properties of Retinoid × Receptor from the Placozoan Trichoplax adhaerens to human

Journal of Steroid Biochemistry and Molecular Biology, 2018
Nuclear receptors are a superfamily of transcription factors restricted to animals. These transcription factors regulate a wide variety of genes with diverse roles in cellular homeostasis, development, and physiology. The origin and specificity of ligand
A. Reitzel, J. Macrander, D. Mané-Padrós, B. Fang, F. Sladek, A. Tarrant   +5 more
semanticscholar   +1 more source