Results 101 to 110 of about 1,756 (166)

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes [PDF]

, 2016
In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc transferase (OGT) catalyzes Ser/ThrO-GlcNAcylation of many cellular proteins and proteolysis of the transcriptional coregulator HCF-1.
Bhuiyan, Tanja, Borodkin, Vladimir S., Herr, Winship, Kapuria, Vaibhav, Röhrig, Ute F., van Aalten, Daan M F, Zoete, Vincent   +6 more
core   +3 more sources

The backbone of the post-synaptic density originated in a unicellular ancestor of choanoflagellates and metazoans

BMC Evolutionary Biology, 2010
Background Comparative genomics of the early diverging metazoan lineages and of their unicellular sister-groups opens new window to reconstructing the genetic changes which preceded or accompanied the evolution of multicellular body plans.
Manuel Michaël, Alié Alexandre
doaj   +1 more source

Steroid Receptors and Vertebrate Evolution

, 2019
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago.
Baker, Michael E.
core  

A Tale of Two Drug Targets: The Evolutionary History of BACE1 and BACE2

Frontiers in Genetics, 2013
The beta amyloid (APP) cleaving enzyme (BACE1) has been a drug target for Alzheimer's Disease (AD) since 1999 with lead inhibitors now entering clinical trials.
Christopher eSouthan, John eHancock
doaj   +1 more source

Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle

Life Science Alliance
Apicortin shapes the Plasmodium cytoskeleton at the apical end without impacting transmission. Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical ...
Mohammad Zeeshan, Akancha Mishra, Sarah L Pashley, Robert Markus, Declan Brady, Anthony A Holder, Carolyn Moores, Rita Tewari   +7 more
doaj   +1 more source

Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

BMC Evolutionary Biology, 2009
Background The question of how genomic processes, such as gene duplication, give rise to co-ordinated organismal properties, such as emergence of new body plans, organs and lifestyles, is of importance in developmental and evolutionary biology.
Moustakas Aristidis, Freilich Shiri, Goldovsky Leon, Huminiecki Lukasz, Ouzounis Christos, Heldin Carl-Henrik   +5 more
doaj   +1 more source

A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location

BMC Evolutionary Biology, 2010
Background The Sp-family of transcription factors are evolutionarily conserved zinc finger proteins present in many animal species. The orthology of the Sp genes in different animals is unclear and their evolutionary history is therefore controversially ...
Wimmer Ernst A, Prpic Nikola-Michael, Schaeper Nina D   +2 more
doaj   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms

Nature Communications
Nucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen, Sergio G. Bartual, Huijie Yuan, Olawale G. Raimi, Andrii Gorelik, Andrew T. Ferenbach, Kristian Lytje, Jan Skov Pedersen, Taner Drace, Thomas Boesen, Daan M. F. van Aalten   +10 more
doaj   +1 more source

Correction: Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens.

PLoS Biology
[This corrects the article DOI: 10.1371/journal.pbio.3001471.].
Angelo Fortunato, Alexis Fleming, Athena Aktipis, Carlo C Maley   +3 more
doaj   +1 more source