Results 81 to 90 of about 1,756 (166)

Importance of fatty acid binding proteins in cellular function and organismal metabolism

Journal of Cellular and Molecular Medicine, Volume 28, Issue 5, March 2024.
Abstract Fatty acid binding proteins (Fabps) are small soluble proteins that are abundant in the cytosol. These proteins are known to bind a myriad of small hydrophobic molecules and have been postulated to serve a variety of roles, yet their precise functions have remained an enigma over half a century of study.
Luis B. Agellon
wiley   +1 more source

An ancient lysozyme in placozoans participates in acidic extracellular digestion

Communications Biology
Lysozymes are an essential part of immunity and nutrition in metazoans, degrading bacterial cell walls via the hydrolysis of peptidoglycan. Although various lysozymes have been reported for higher animals, the origin of animal lysozymes remains elusive ...
Henry Berndt, Igor Duarte, Urska Repnik, Michel A. Struwe, Mohammad Abukhalaf, Axel J. Scheidig, Andreas Tholey, Harald R. Gruber-Vodicka, Matthias Leippe   +8 more
doaj   +1 more source

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release [PDF]

, 2010
The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion. Previous studies are consistent with Cpx functioning either as a synaptic vesicle fusion clamp to prevent premature exocytosis, or as a facilitator to ...
Cho, Richard W., Littleton, J. Troy, Song, Yun   +2 more
core   +1 more source

Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses

Journal of Experimental Biology, 2017
ABSTRACT Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and grazes on algae. Trichoplax displays a repertoire of different feeding behaviors despite the apparent absence of a true nervous system with electrical or chemical synapses. It glides along surfaces to find food, propelled by beating cilia
Adriano Senatore, Thomas S. Reese, Carolyn L. Smith   +2 more
openaire   +2 more sources

Short and random: Modelling the effects of (proto-)neural elongations [PDF]

, 2017
To understand how neurons and nervous systems first evolved, we need an account of the origins of neural elongations: Why did neural elongations (axons and dendrites) first originate, such that they could become the central component of both neurons and ...
de Wiljes, Oltman O., Keijzer, Fred A., van Elburg, Ronald A. J.   +2 more
core   +3 more sources

Features of a novel protein, rusticalin, from the ascidian Styela rustica reveal ancestral horizontal gene transfer event

Mobile DNA, 2019
Background The transfer of genetic material from non-parent organisms is called horizontal gene transfer (HGT). One of the most conclusive cases of HGT in metazoans was previously described for the cellulose synthase gene in ascidians.
Maria A. Daugavet, Sergey Shabelnikov, Alexander Shumeev, Tatiana Shaposhnikova, Leonid S. Adonin, Olga Podgornaya   +5 more
doaj   +1 more source

Evolution of the TGF-β signaling pathway and its potential role in the ctenophore, Mnemiopsis leidyi. [PDF]

PLoS ONE, 2011
The TGF-β signaling pathway is a metazoan-specific intercellular signaling pathway known to be important in many developmental and cellular processes in a wide variety of animals. We investigated the complexity and possible functions of this pathway in a
Kevin Pang, Joseph F Ryan, Andreas D Baxevanis, Mark Q Martindale   +3 more
doaj   +1 more source

Conservation of context-dependent splicing activity in distant Muscleblind homologs [PDF]

, 2016
The Muscleblind (MBL) protein family is a deeply conserved family of RNA binding proteins that regulate alternative splicing, alternative polyadenylation, RNA stability and RNA localization. Their inactivation due to sequestration by expanded CUG repeats
Berglund, J. Andrew, McConnell, Ona L., Oddo, Julia Christine, Saxena, Tanvi, Wang, Eric T   +4 more
core   +1 more source

On an Evolutionary Foundation of Neuroeconomics [PDF]

Neuroeconomics focuses on brain imaging studies mapping neural responses to choice behavior. Economic theory is concerned with choice behavior but it is silent on neural activities.
Burkhard C. Schipper
core   +3 more sources

Evolutionary insights into premetazoan functions of the neuronal protein homer. [PDF]

, 2014
Reconstructing the evolution and ancestral functions of synaptic proteins promises to shed light on how neurons first evolved. The postsynaptic density (PSD) protein Homer scaffolds membrane receptors and regulates Ca(2+) signaling in diverse metazoan ...
Burkhardt, Pawel, Grønborg, Mads, KING, Nicole, McDonald, Kent, Sulur, Tara, Wang, Qi   +5 more
core   +1 more source