Results 61 to 70 of about 1,730 (164)
FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar +7 more
wiley +1 more source
Phylogenetic analysis of the endoribonuclease Dicer family. [PDF]
PLoS ONE, 2014 Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved in regulation of gene expression at the post-transcriptional level.
Zeqian Gao +4 more
doaj +1 more source
Molecular mechanisms of perilipin protein function in lipid droplet metabolism
FEBS Letters, Volume 598, Issue 10, Page 1170-1198, May 2024.Lipid droplets (LDs) are important for the storage of energy and lipid components. The perilipin family in mammals includes five proteins (PLIN1 to PLIN5), all of which are abundant on the surface of LDs in different tissues and play a role in LD stability and degradation by lipases.
Elena Griseti +7 more
wiley +1 more source
Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis. [PDF]
PLoS ONE, 2015 The heparan sulfate proteoglycan 2 (HSPG2)/perlecan gene is ancient and conserved in all triploblastic species. Its presence maintains critical cell boundaries in tissue and its large (up to ~900 kDa) modular structure has prompted speculation about the ...
Curtis R Warren +5 more
doaj +1 more source
Beauty in the beast – Placozoan biodiversity explored through molluscan predator genomics
Ecology and Evolution, Volume 14, Issue 4, April 2024.Previous assumptions about the primary habitat of Placozoa are challenged, and their broader diversity beyond disc‐shaped grazers in coastal waters is revealed. The discovery of placozoan‐predatory sea slugs prompts consideration of a new ecological niche: seafloor sediment interstices.
Michael Eitel +3 more
wiley +1 more source
Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens [PDF]
Scientific Reports, 2016 AbstractThe identification of genes encoding a p53 family member and an Mdm2 ortholog in the ancient placozoan Trichoplax adhaerens advocates for the evolutionary conservation of a pivotal stress-response pathway observed in all higher eukaryotes. Here, we recapitulate several key functionalities ascribed to this known interacting protein pair by ...
Siau, J.W +7 more
openaire +3 more sources
Proteoglycans in mechanobiology of tissues and organs: Normal functions and mechanopathology
Proteoglycan Research, Volume 2, Issue 2, April-June 2024.Abstract Proteoglycans (PGs) are a diverse class of glycoconjugates that serve critical functions in normal mechanobiology and mechanopathology. Both the protein cores and attached glycosaminoglycan (GAG) chains function in mechanically sensitive processes, and loss of either can contribute to development of pathological conditions. PGs function as key
Mary C. Farach‐Carson +2 more
wiley +1 more source
Importance of fatty acid binding proteins in cellular function and organismal metabolism
Journal of Cellular and Molecular Medicine, Volume 28, Issue 5, March 2024.Abstract Fatty acid binding proteins (Fabps) are small soluble proteins that are abundant in the cytosol. These proteins are known to bind a myriad of small hydrophobic molecules and have been postulated to serve a variety of roles, yet their precise functions have remained an enigma over half a century of study.
Luis B. Agellon
wiley +1 more source
Phylogenetic position of Placozoa based on large subunit (LSU) and small subunit (SSU) rRNA genes
Genetics and Molecular Biology, 2007 The phylum Placozoa, represented by its single species Trichoplax adhaerens, has always been considered one of the most basal animal clades due to its low morphological complexity.
Fernanda Britto da Silva +2 more
doaj +1 more source
Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
Journal of Experimental Biology, 2017 ABSTRACT Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and grazes on algae. Trichoplax displays a repertoire of different feeding behaviors despite the apparent absence of a true nervous system with electrical or chemical synapses. It glides along surfaces to find food, propelled by beating cilia
Adriano Senatore +2 more
openaire +2 more sources