Results 61 to 70 of about 1,756 (166)

Getting Nervous: An Evolutionary Overhaul for Communication. [PDF]

, 2017
The evolution of a nervous system as a control system of the body's functions is a key innovation of animals. Its fundamental units are neurons, highly specialized cells dedicated to fast cell-cell communication.
Fasshauer, D., Varoqueaux, F.
core   +1 more source

The cobalamin processing enzyme of Trichoplax adhaerens

Journal of Biological Chemistry
Cobalamin (Cbl) is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase, but it must first undergo chemical processing for utilization in animals. In humans, this processing comprises β-axial ligand cleavage and Cbl reduction and is performed by the enzyme MMACHC (HsCblC).
Caroline Krams, Anna J. Esser, Melissa Klenzendorf, Katharina Klotz, Ute Spiekerkoetter, Donald W. Jacobsen, Clyde A. Smith, Ailiena O. Maggiolo, Luciana Hannibal   +8 more
openaire   +3 more sources

Domain‐Shuffling in the Evolution of Cyclostomes and Gnathostomes

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 344, Issue 2, Page 59-79, March 2025.
We addressed the potential roles of domain‐shuffling origin genes (DSO‐Gs) in the evolution of early vertebrates. Through comparative genome analysis of 22 metazoans, including four cyclostomes, we identified DSO‐Gs before and after the divergence of cyclostomes and gnathostomes, and suggest domain shuffling as a key mechanism in vertebrate early ...
Hirofumi Kariyayama, Takeshi Kawashima, Hiroshi Wada, Haruka Ozaki   +3 more
wiley   +1 more source

Distinct expression patterns of the two T-box homologues Brachyury and Tbx2/3 in the placozoan Trichoplax adhaerens [PDF]

, 2018
Trichoplax adhaerens is the only species known from the phylum Placozoa with one of the simplest metazoan body plans. In the small disc-like organism an upper and a lower epithelium can be distinguished with a less compact third cell layer in between ...
Martinelli, Cosimo, Spring, Jürg
core  

Developmental gene expression in the eyes of the pygmy squid Xipholeptos notoides

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 342, Issue 7, Page 483-498, November 2024.
In the cephalopod Xipholeptos notoides, the photosensitive pigment encoding genes Rhodopsin, Xenopsin, and Retinochrome, as well as two Reflectin genes are expressed in the olfactory organ. This suggests that either opsins may not only be involved in photoreception or the olfactory organ is involved in photoreception.
David Koller, Kevin M. Kocot, Bernard M. Degnan, Tim Wollesen   +3 more
wiley   +1 more source

Studying Placozoa WBR in the Simplest Metazoan Animal, Trichoplax adhaerens

, 2022
AbstractPlacozoans are a promising model system to study fundamental regeneration processes in a morphologically and genetically very simple animal. We here provide a brief introduction to the enigmatic Placozoa and summarize the state of the art of animal handling and experimental manipulation possibilities.
Hans-Jürgen Osigus, Michael Eitel, Karolin Horn, Kai Kamm, Jennifer Kosubek-Langer, Moritz Jonathan Schmidt, Heike Hadrys, Bernd Schierwater   +7 more
openaire   +2 more sources

Evolution of the Cdk4/6–Cdkn2 system in invertebrates

Genes to Cells, Volume 29, Issue 11, Page 1037-1051, November 2024.
Hypothesis on the evolution of the Cdkn2 locus. (a) Loss of Cdkn2 occurred multiple times. (b) Evolution of microsynteny at the Cdkn2 locus. Cdkn2e is a hypothetical transient gene. Abstract The cell cycle is driven by cyclin‐dependent kinases (Cdks). The decision whether the cell cycle proceeds is made during G1 phase, when Cdk4/6 functions.
Shiori Yuki, Shunsuke Sasaki, Yuta Yamamoto, Fumika Murakami, Kazumi Sakata, Isato Araki   +5 more
wiley   +1 more source

The origin and evolution of G protein-coupled receptor kinases. [PDF]

PLoS ONE, 2012
G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling.
Arcady Mushegian, Vsevolod V Gurevich, Eugenia V Gurevich   +2 more
doaj   +1 more source

The origin of the Hox/ParaHox genes, the Ghost Locus hypothesis and the complexity of the first animal [PDF]

, 2015
A key aim in evolutionary biology is to deduce ancestral states in order to better understand the evolutionary origins of clades of interest and the diversification process(es) that have elaborated them.
Ferrier, David E. K.
core   +1 more source

Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs

FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.
This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar, Juan P. Pardo, Adela Rodríguez‐Romero, Alejandro Sosa‐Peinado, Luz Vásquez‐Bochm, Patricia Cano‐Sánchez, Laura Iliana Álvarez‐Añorve, Martin González‐Andrade   +7 more
wiley   +1 more source