Results 71 to 80 of about 2,412 (183)

Global diversity of the Placozoa.

PLoS ONE, 2013
The enigmatic animal phylum Placozoa holds a key position in the metazoan Tree of Life. A simple bauplan makes it appear to be the most basal metazoan known and genetic evidence also points to a position close to the last common metazoan ancestor ...
Michael Eitel, Hans-Jürgen Osigus, Rob DeSalle, Bernd Schierwater   +3 more
doaj   +1 more source

Beyond the Secretory Pathway: New Insights Into Protein Release

Traffic, Volume 26, Issue 10-12, October/December 2025.
While proteins bearing N‐terminal signal or leader sequences are secreted via the ER‐Golgi‐plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequence can be secreted via poorly defined mechanisms termed Unconventional Protein Secretion (UcPS).
Ruey‐Hwa Chen, Antonio J. Costa‐Filho, Jayanta Debnath, Thierry Galli, Liang Ge, Deborah Goberdhan, Wei Guo, Kangmin He, Ralf Jacob, Tiebang Kang, Min Goo Lee, Lian Li, Fabio Lolicato, Jun Lu, Vivek Malhotra, Walter Nickel, Vassiliki Nikoletopoulou, Stacey K. Ogden, Georgia Maria Sagia, Feng Shao, Anbing Shi, Clotilde Thery, Christel Vérollet, Julien Villeneuve, Frederik Verweij, Yanzhuang Wang, Juan Wang, Shenjie Wu, Yihong Ye, Hang Yin, Li Yu, Min Zhang, Ying Zhang, Xin Zhou, Chiara Zurzolo   +34 more
wiley   +1 more source

Comparative genomics and the nature of placozoan species. [PDF]

PLoS Biology, 2018
Placozoans are a phylum of nonbilaterian marine animals currently represented by a single described species, Trichoplax adhaerens, Schulze 1883. Placozoans arguably show the simplest animal morphology, which is identical among isolates collected ...
Michael Eitel, Warren R Francis, Frédérique Varoqueaux, Jean Daraspe, Hans-Jürgen Osigus, Stefan Krebs, Sergio Vargas, Helmut Blum, Gray A Williams, Bernd Schierwater, Gert Wörheide   +10 more
doaj   +1 more source

Invertebrate Bile Acid‐Sensitive Ion Channels and Their Emergence in Bilateria

The FASEB Journal, Volume 39, Issue 8, 30 April 2025.
This graphical abstract presents the evolutionary distribution and functional characteristics of bile acid‐sensing ion channels (BASICs) across bilaterians. A phylogenetic tree illustrates the presence of BASICs in diverse groups, extending beyond previously established mammalian findings.
Josep Martí‐Solans, Aina Børve, Line Vevle, Andreas Hejnol, Timothy Lynagh   +4 more
wiley   +1 more source

Domain‐Shuffling in the Evolution of Cyclostomes and Gnathostomes

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 344, Issue 2, Page 59-79, March 2025.
We addressed the potential roles of domain‐shuffling origin genes (DSO‐Gs) in the evolution of early vertebrates. Through comparative genome analysis of 22 metazoans, including four cyclostomes, we identified DSO‐Gs before and after the divergence of cyclostomes and gnathostomes, and suggest domain shuffling as a key mechanism in vertebrate early ...
Hirofumi Kariyayama, Takeshi Kawashima, Hiroshi Wada, Haruka Ozaki   +3 more
wiley   +1 more source

Developmental gene expression in the eyes of the pygmy squid Xipholeptos notoides

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 342, Issue 7, Page 483-498, November 2024.
In the cephalopod Xipholeptos notoides, the photosensitive pigment encoding genes Rhodopsin, Xenopsin, and Retinochrome, as well as two Reflectin genes are expressed in the olfactory organ. This suggests that either opsins may not only be involved in photoreception or the olfactory organ is involved in photoreception.
David Koller, Kevin M. Kocot, Bernard M. Degnan, Tim Wollesen   +3 more
wiley   +1 more source

Evolution of the Cdk4/6–Cdkn2 system in invertebrates

Genes to Cells, Volume 29, Issue 11, Page 1037-1051, November 2024.
Hypothesis on the evolution of the Cdkn2 locus. (a) Loss of Cdkn2 occurred multiple times. (b) Evolution of microsynteny at the Cdkn2 locus. Cdkn2e is a hypothetical transient gene. Abstract The cell cycle is driven by cyclin‐dependent kinases (Cdks). The decision whether the cell cycle proceeds is made during G1 phase, when Cdk4/6 functions.
Shiori Yuki, Shunsuke Sasaki, Yuta Yamamoto, Fumika Murakami, Kazumi Sakata, Isato Araki   +5 more
wiley   +1 more source

The origin and evolution of G protein-coupled receptor kinases. [PDF]

PLoS ONE, 2012
G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling.
Arcady Mushegian, Vsevolod V Gurevich, Eugenia V Gurevich   +2 more
doaj   +1 more source

Protein tyrosine phosphatase 1B (PTP1B) function, structure, and inhibition strategies to develop antidiabetic drugs

FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.
This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar, Juan P. Pardo, Adela Rodríguez‐Romero, Alejandro Sosa‐Peinado, Luz Vásquez‐Bochm, Patricia Cano‐Sánchez, Laura Iliana Álvarez‐Añorve, Martin González‐Andrade   +7 more
wiley   +1 more source

Molecular 16S rDNA diagnostics for the genera Hoilungia and Trichoplax.

, 2018
Molecular 16S rDNA diagnostics for the genera Hoilungia and Trichoplax.
Warren R. Francis (763154), Sergio Vargas (154238), Stefan Krebs (157539), Helmut Blum (157522), Gert Wörheide (35547), Michael Eitel (123756), Frédérique Varoqueaux (5574755), Jean Daraspe (5574758), Bernd Schierwater (123767), Hans-Jürgen Osigus (267552), Gray A. Williams (169132)   +10 more
core   +1 more source