Results 131 to 140 of about 1,374 (169)
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Teratogenic evaluation of triclabendazole in rats
Toxicology, 1987Triclabendazole, a new benzimidazole anthelmintic, was administered by gavage to pregnant rats at 0 (control), 10, 25, 50, 100 or 200 mg/kg on days 8 through 15 of pregnancy. The dams were killed on day 21 of pregnancy, and the fetuses were examined by routine teratological methods.
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Solving the Delivery Problems of Triclabendazole Using Cyclodextrins
AAPS PharmSciTech, 2018Triclabendazole is the first-line drug of choice to treat and control fasciolasis, a neglected parasitic human disease. It is a class II/IV compound according to the Biopharmaceutics Classification System. Thus, the aim of this study was to improve aqueous solubility and dissolution rate of triclabendazole complexed with 2-hydroxylpropyl-β-cyclodextrin
Real, Daniel Andres +4 more
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Control ofFasciola gigantica with triclabendazole in Indonesian cattle
Tropical Animal Health and Production, 1991The efficacy of triclabendazole (TCBZ) against natural infections with Fasciola gigantica was evaluated in a field study using 102 Indonesian cattle. The animals were divided into two groups; one received TCBZ at 12 mg/kg orally every eight weeks for one year while the other remained untreated.
, Suhardono +3 more
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Raising the bar on reporting ‘triclabendazole resistance’
Veterinary Record, 2011Exaggerated and potentially false claims of resistance to triclabendazole may be hampering control of fasciolosis by encouraging farmers to use less effective products, says Ian Fairweather , who argues for more accurate diagnosis before such claims are made THERE is much evidence to indicate that the incidence of fasciolosis has increased in recent ...
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Efficacy and pharmacokinetics of triclabendazole in buffalo with induced fasciolosis
Veterinary Parasitology, 1996A study was conducted to understand pharmacokinetics and flukicidal activity of intraruminal administration of triclabendazole (TCBZ) at 12.0, 24.0 and 36.0 mg kg-1 body weight in experimentally Fasciola gigantica-infected buffaloes on Week 2 and 10 post-infection.
P K, Sanyal, S C, Gupta
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A Molecular Modeling Approach to In vivo Efficacy of Triclabendazole
The Journal of Parasitology, 1991The structural and electronic features of a narrow-spectrum benzimidazole anthelmintic triclabendazole (TCZ, 6-chloro-5-[2,3-dichlorophenoxy]-2-methylthio-benzimidazole) and its 2 main metabolites triclabendazole sulfoxide (TCZ sulfoxide, 6-chloro-5-[2,3-dichlorophenoxyl]-2-methylsulfonyl-benzimidazole) and triclabendazole sulfone (TCZ sulfone, 6 ...
K B, Lipkowitz, R O, McCracken
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SOLID DISPERSIONS OF TRICLABENDAZOLE AND THEIR PROPERTIES
THEORY AND PRACTICE OF PARASITIC DISEASE CONTROLThe study purpose: systematization of research results on the production technology and properties of triclabendazole (TCB)-based solid dispersions and polymer substances. Research results: we performed the analysis of technology features for producing solid dispersions (SDs) of the TCB substance with various polymeric substances ...
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