Triclabendazole inhibits PKM2 nuclear localization and glycolysis by enhancing HDAC6-mediated deacetylation in lung cancer [PDF]
Journal of Translational MedicineBackground Metabolic reprogramming is a hallmark of cancer cells, enabling them to meet the heightened energetic and biosynthetic demands required for rapid growth and proliferation.
Liang Yan +9 more
doaj +2 more sources
Triclabendazole disrupts mitochondrial electron transport in vitro [PDF]
Antimicrobial Agents and ChemotherapyMitochondrial respiration, which relies on succinate dehydrogenase (SDH), among other factors, is essential for cellular energy metabolism. This study shows that triclabendazole and its primary metabolites inhibit SDH in mitochondria of the cestode ...
Tobias Kämpfer +7 more
doaj +2 more sources
The effects of triclabendazole, combined tetramisole with Oxyclozanide, and albendazole against ovine fasciolosis [PDF]
Scientific ReportsRecent estimates suggest that liver condemnation due to liver fluke in Ethiopia causes an annual economic loss of about 48.4 million Ethiopian birr. For approximately ten decades, the treatment of fasciolosis has relied solely on triclabendazole (TCBZ ...
Tameru Gedefaw +3 more
doaj +2 more sources
Clinical, laboratory features and treatment outcomes of patients infected with Fasciola in Northern Vietnam, 2019–2023 [PDF]
Tropical Diseases, Travel Medicine and VaccinesBackground Vietnam experiences a significant occurrence of fascioliasis infection, largely due to the common practice of consuming raw vegetables. Diagnosing the fascioliasis infection remains difficult, and patients endure various long-term consequences.
Nguyen Kim Thu +3 more
doaj +2 more sources
Medecine tropicale : revue du Corps de sante colonial, 2012 Triclabendazole is indicated for treatment of human fascioliasis, a widespread disease. Treatment is straightforward and generally well tolerated. However, increasing resistance to this therapy has been observed since the 1990s. Research is being carried out to develop new medications with special interest in artesunate.
Hoofnagle JH.
europepmc +2 more sources
High Efficacy of Triclabendazole/Ivermectin Combination Compared to Triclabendazole Monotherapy for Treating Human Fascioliasis in Upper Egypt: A Prospective Study [PDF]
Tropical Medicine and Infectious DiseaseTriclabendazole (TCBZ) is the gold standard treatment for fascioliasis. However, reports on resistance are increasing, emphasizing the need for alternative therapy.
Waleed Attia Hassan +4 more
doaj +2 more sources
A Stability-Indicating RP-HPLC Method for Simultaneous Determination of Triclabendazole and Levamisole in Oral Suspension Formulation. [PDF]
Int J Anal ChemA fast, simple, and precise stability‐indicating high‐performance liquid chromatographic (HPLC) method was developed for analysis of triclabendazole (TBZ) and levamisole (LEV) in oral suspension. Using a mobile phase composed of acetonitrile, methanol, and water (50:40:10, v/v/v), with the pH adjusted to 4.6 with 0.1 M phosphoric acid. The mobile phase
Elbashir AA, Hamid KMM.
europepmc +2 more sources
Distinct gut microbiome features characterize Fasciola hepatica infection and predict triclabendazole treatment outcomes in Peruvian patients [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundFasciola hepatica, a globally distributed helminth, causes fasciolosis, a disease with significant health and economic impacts. Variability in triclabendazole (TCBZ) efficacy and emerging resistance are remaining challenges.
Giljae Lee +10 more
doaj +2 more sources
Oxidative impact of dietary triclabendazole in galleria mellonella [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Recent studies have shown that anthelmintic and antifungal agents are recommended as alternative agents in chemical control of insect pests. In this study, first instar larvae of the greater wax moth, Galleria mellonella, were reared on artificial diets ...
Ender BÜYÜKGÜZEL +1 more
doaj +1 more source
Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells
Frontiers in Pharmacology, 2021 Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation.
Liang Yan +12 more
doaj +1 more source