Results 1 to 10 of about 109,999 (323)

Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide [PDF]

Scientific Reports
Ionotropic glycine receptors (GlyRs) are chloride-permeable ligand-gated ion channels expressed in the nervous system. Alterations to glycinergic inhibition and the generation of dysfunctional GlyRs have been linked to chronic pain, a widely prevalent ...
César O. Lara, Carlos F. Burgos, Katherine Fariña-Oliva, Ana M. Marileo, Victoria P. San Martín, David Flaig, Paul Soto-Ortega, Omayra V. Contreras, Anggelo Sazo, Krishna Gaete-Riquelme, Jeremías Corradi, Carola Muñoz-Montesino, Jorge Fuentealba, Patricio A. Castro, Luis G. Aguayo, Cecilia Bouzat, Gustavo Moraga-Cid, Gonzalo E. Yévenes   +17 more
doaj   +2 more sources

The Brugada Type 1 Electrocardiogram and Ventricular Tachycardia With High-Dose Amitriptyline

JACC: Case Reports, 2021
A 32-year-old woman with anorexia nervosa experienced ventricular tachycardia while on therapeutic-dose amitriptyline despite normal blood tests, imaging, and intracardiac recordings.
Ji-Jian Chow, MRCP, Nandita Kaza, MBChB, Amanda Varnava, MD   +2 more
doaj   +1 more source

EXTREMAL IOTA ENERGY OF A SUBCLASS OF TRICYCLIC DIGRAPHS AND SIDIGRAPHS [PDF]

Matrix Science Mathematic, 2018
The iota energy of an n-vertex digraph D is defined by Ec (𝐷) = ∑ 􀀀1 |Im(𝑧 k)|, where z1, . . ., zn are eigenvalues of D and Im(zk) is the imaginary part of eigenvalue zk . The iota energy of an n-vertex sidigraph can be defined analogously.
Fareeha Jamal, Mehtab Khan
doaj   +1 more source

Structure-activity relationship analysis and molecular structure construction of fused tricyclic energetic molecules containing flexible ring

Energetic Materials Frontiers, 2023
A simple, mild and efficient method was proposed to construct fused tricyclic skeletons based on Mannich reaction. This work not only develops a new method to construct the tricyclic skeletons effectively, but also provides a new insight into the fused ...
Jun-hao Shi, Hong-lei Xia, Si-wei Song, Si-tong Chen, Zi-wu Cai, Yu-teng Cao, Wen-quan Zhang   +6 more
doaj   +1 more source

Fixed Points Results for Various Types of Tricyclic Contractions

Axioms, 2021
In this paper, we introduce four new types of contractions called in this order Kanan-S-type tricyclic contraction, Chattergea-S-type tricyclic contraction, Riech-S-type tricyclic contraction, Cirić-S-type tricyclic contraction, and we prove the ...
Mustapha Sabiri, Abdelhafid Bassou, Jamal Mouline, Taoufik Sabar   +3 more
doaj   +1 more source

Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter

Pharmaceutics, 2020
The cellular delivery of cell-impermeable and water-insoluble molecules remains an ongoing challenge to overcome. Previously, we reported amphipathic cyclic peptides c[WR]4 and c[WR]5 consisting of alternate arginine and tryptophan residues as nuclear ...
Sumit Kumar, Dindyal Mandal, Shaima Ahmed El-Mowafi, Saghar Mozaffari, Rakesh Kumar Tiwari, Keykavous Parang   +5 more
doaj   +1 more source

Distribution of Steranes and Triterpanes Biomarkersas Indication of Depositional Environment and Maturity of Sargelu and Kurrachine Formations in Different Wells Northern Iraq

Iraqi Geological Journal, 2021
Eight cuttings samples were obtained from Sargelu and Kurrachine formations in different wells at different depths to detect steranes and triterpanes biomarkers as an indicator of the depositional environments and thermal maturity of organic matter. This
Al-Dolaimy, Arwa
doaj   +1 more source

Fused Tricyclic Guanidine Alkaloids: Insights into Their Structure, Synthesis and Bioactivity

Marine Drugs, 2022
A marine natural product possesses a diverse and unique scaffold that contributes to a vast array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine natural products.
Nur Zahirah Abd Rani, Yean Kee Lee, Sarfraz Ahmad, Ramu Meesala, Iskandar Abdullah   +4 more
doaj   +1 more source

Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function.

Frontiers in Pharmacology, 2013
Depression is a major health problem for which most patients are not effectively treated. This problem is further compounded in children and adolescents where only two antidepressants [both selective serotonin reuptake inhibitors (SSRIs)] are currently
Nathan C Mitchell, Georgianna G Gould, Corey M Smolik, Wouter eKoek, Lynette C Daws   +4 more
doaj   +1 more source

Path energy of two kinds of special tricyclic graphs

Journal of Hebei University of Science and Technology, 2020
Aiming at the problem that there are many kinds of tricyclic graphs and the complexity of path matrix is high, the path energy of two kinds of tricyclic graphs with or without pendant vertices was studied by means of matrix analysis, the existence ...
Wenjing LI, Yanling SHAO
doaj   +1 more source