Results 61 to 70 of about 34,503 (265)
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.In women with hormone‐resistant chronic pelvic pain, central sensitization is highly prevalent and independently associated with significant quality‐of‐life impairment and increased analgesic burden. These findings highlight the need for systematic screening of sensitization and trauma to optimize multidisciplinary management in specialized care ...
Hajar Alawadi +3 more
wiley +1 more source
Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
Frontiers in Physiology, 2014 Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain.
Nadine eBeckmann +4 more
doaj +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen +3 more
wiley +1 more source
Unravelling the efficacy of antidepressants as analgesics [PDF]
, 2016 Background: Chronic pain is a large and growing public health concern in Australia. Chronic pain is generally associated with physical, psychological, social and cultural risk factors.
Janakiraman, Raguraman +2 more
core
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Medicare Part D prescribing changes of tricyclic antidepressants between 2013 and 2014 [PDF]
, 2017 PdfTricyclic antidepressants were the primary pharmacologic treatment for depression in the United States from the 1960s to the late 1980s. Since then, other classes of antidepressants, such as Selective Serotonin Reuptake Inhibitors, have replaced its ...
Taira, Deborah, So, Nadine W.
core +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Enhancement of morphine analgesia by tricyclic antidepressants [PDF]
, 1979 Using a cat tail-flick analgetic testing procedure, enhancement of the antinociceptive action of morphine (0.25 mg/kg s.c.) was detected following pre-treatment (1 hour) with 10 mg/kg s.c. of either amitriptyline or nortriptyline.
Goldstein, Frederick J., Malseed, R. T.
core
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Observed and modelled prescription rates for individual (A) Selective Serotonin Reuptake Inhibitors (SSRIs) and (B) Tricyclic Antidepressants (TCAs). [PDF]
, 2013 Observed and modelled prescription rates for individual (A) Selective Serotonin Reuptake Inhibitors (SSRIs) and (B) Tricyclic Antidepressants (TCAs).
Irwin Nazareth (144882) +2 more
core +1 more source