Results 41 to 50 of about 34,503 (265)
Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives
Molecules, 2005 Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-
Vladimir Vinkovic +3 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire +3 more
wiley +1 more source
An update on the treatment of premature ejaculation: A systematic review
Arab Journal of Urology, 2021 To analyse the current therapeutic options for patients with premature ejaculation (PE) and highlight their mechanism(s) of action, effectiveness, advantages and limitations.
Ramadan Saleh +2 more
doaj +1 more source
Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states [PDF]
, 2008 Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of inhibition of homomeric 5-HT(3A)
Gumilar, Fernanda Andrea +1 more
core +1 more source
Conditional effect of age in the association between the use of benzodiazepines, opioids and tricyclic antidepressants and falls. [PDF]
, 2020 Conditional effect of age in the association between the use of benzodiazepines, opioids and tricyclic antidepressants and falls.
Raquel Vilar-López (2816281) +4 more
core +1 more source
PLoS ONE, 2015 ObjectivesTo estimate the effect of pharmacotherapy on PTSD, anxiety, and depression among combat veterans; to determine whether the effects varied according to patient and intervention characteristics; and to examine differential effects of ...
Timothy W Puetz +2 more
doaj +1 more source
Sociodemographic factors of violent deaths related to licit or ilicit psychoactive substances: a cross-sectional study, Ceará, Brazil, 2015-2019 [PDF]
Epidemiologia e Serviços de SaúdeObjective To assess association between sociodemographic factors, presence of licit or illicit psychoactive substances, and types of legal death in Ceará state, Brazil.
Wanderley Pinheiro de Holanda Júnior +2 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz +2 more
wiley +1 more source
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
Nature Communications, 2020 Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential ...
Philip E. D. Chung +20 more
doaj +1 more source
Tricyclic antidepressant poisoning
Cleveland Clinic Journal of Medicine, 2000 Tricyclic antidepressant poisoning causes predictable electrocardiographic abnormalities and can be lethal. Cardiac arrhythmias, hypotension, seizures, and coma are common. Sodium bicarbonate is still considered the treatment of choice for severe toxicity, although a variety of supportive measures may be taken.
openaire +2 more sources