Results 41 to 50 of about 85,814 (252)
Translational development of crisugabalin for neuropathic pain
British Journal of Clinical Pharmacology, EarlyView.Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João +5 more
wiley +1 more source
Drug Testing and Analysis, EarlyView.This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum +4 more
wiley +1 more source
PLoS ONE, 2015 ObjectivesTo estimate the effect of pharmacotherapy on PTSD, anxiety, and depression among combat veterans; to determine whether the effects varied according to patient and intervention characteristics; and to examine differential effects of ...
Timothy W Puetz +2 more
doaj +1 more source
Medicare Part D prescribing changes of tricyclic antidepressants between 2013 and 2014 [PDF]
, 2017 PdfTricyclic antidepressants were the primary pharmacologic treatment for depression in the United States from the 1960s to the late 1980s. Since then, other classes of antidepressants, such as Selective Serotonin Reuptake Inhibitors, have replaced its ...
Taira, Deborah, So, Nadine W.
core
Tricyclic Antidepressants [PDF]
Tricyclic antidepressants (TCAs), one of the most common causes of death from poisoning, are used to treat major depression and other medical disorders. They have a lipophilic structure and high potential for bioconcentration.
مصطفی لو, سارا +1 more
core +1 more source
Epilepsia Open, EarlyView.Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort of adults with comorbid migraine and epilepsy treated with anti‐CGRP ...
Marina Romozzi +13 more
wiley +1 more source
Sociodemographic factors of violent deaths related to licit or ilicit psychoactive substances: a cross-sectional study, Ceará, Brazil, 2015-2019 [PDF]
Epidemiologia e Serviços de SaúdeObjective To assess association between sociodemographic factors, presence of licit or illicit psychoactive substances, and types of legal death in Ceará state, Brazil.
Wanderley Pinheiro de Holanda Júnior +2 more
doaj +1 more source
Frontiers in Public Health, 2015 Background: Recent studies have highlighted associations between use of antidepressant medications and coronary heart disease (CHD). Tricyclic antidepressants are not recommended in patients with CHD as they may increase morbidity and mortality. However,
Andrew eKemp
doaj +1 more source
, 2013 Observed and modelled prescription rates for individual (A) Selective Serotonin Reuptake Inhibitors (SSRIs) and (B) Tricyclic Antidepressants (TCAs).
Irwin Nazareth (144882) +2 more
core +1 more source
Transperineal Ultrasound in Chronic Pelvic Pain: A Systematic Review
Journal of Clinical Ultrasound, EarlyView.Graphical abstract illustrating the systematic review process and highlighting key pelvic floor musculature (PFM) alterations detected by transperineal ultrasound (TPU) in patients with chronic pelvic pain (CPP) and associated conditions. These findings provide insights to enhance understanding and management of CPP.
Giulia Paoni Saccone +10 more
wiley +1 more source