Results 41 to 50 of about 52,474 (198)
Arthritis &Rheumatology, EarlyView.Objective Nociplastic pain is pain primarily driven by the central nervous system and, unlike nociceptive pain conditions, is thought to be refractory to peripherally directed therapies. Nociplastic pain is also associated with hypersensitivity to painful and other sensory stimuli (such as visual stimuli). Nonpainful sensory measures have not been well
Noah Waller +15 more
wiley +1 more source
Considerations for the use of anesthesia in patients undergoing tricyclic antidepressant treatment
Medisur, 2017 Patients undergoing tricyclic antidepressant treatment given anesthesia have experienced the hypotensive effects of both drugs. Traditionally it was recommended to suspend these drugs until two weeks before surgery; however, it is currently proposed that
Iván Hamyd Salazar Carrera
doaj +2 more sources
Synthesis of Novel, Potentially Biologically Active Dibenzosuberone Derivatives
Molecules, 2005 Novel representatives of the important group of biologically active dibenzosuberone derivatives were prepared: 3,7-dibromo-5-(dimethylaminoethyl- oxyimino)-10,11-dihydro-5H-dibenzo[a,d]cyclohepta-1,4-diene (1), 3,7-dibromo-5-(3- dimethylaminopropylidene)-
Vladimir Vinkovic +3 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Hyponatremia is a common yet potentially serious adverse event associated with antidepressants. Identifying the antidepressant class with the least risk of hyponatremia would improve patient safety. Methods Using electronic medical records from 15 hospitals standardized into Observational Medical Outcomes Partnership Common Data Model (2003–2023 ...
Kyungyeon Jung +21 more
wiley +1 more source
PLoS ONE, 2015 ObjectivesTo estimate the effect of pharmacotherapy on PTSD, anxiety, and depression among combat veterans; to determine whether the effects varied according to patient and intervention characteristics; and to examine differential effects of ...
Timothy W Puetz +2 more
doaj +1 more source
Sociodemographic factors of violent deaths related to licit or ilicit psychoactive substances: a cross-sectional study, Ceará, Brazil, 2015-2019 [PDF]
Epidemiologia e Serviços de SaúdeObjective To assess association between sociodemographic factors, presence of licit or illicit psychoactive substances, and types of legal death in Ceará state, Brazil.
Wanderley Pinheiro de Holanda Júnior +2 more
doaj +1 more source
Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. [PDF]
, 2004 We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing.
Araki, Hiroaki +5 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Individual second‐generation antihistamines may possess differential sedative potential due to the variability in central histamine receptor H1 occupancy. This study aimed to evaluate whether the sedative potential of second‐generation antihistamines is associated with the risk of injury during Japan's pollen season. Methods We conducted a
Jumpei Taniguchi +3 more
wiley +1 more source
Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
Nature Communications, 2020 Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential ...
Philip E. D. Chung +20 more
doaj +1 more source