Results 161 to 170 of about 3,603 (218)

The Trifluoromethyl Anion

Angewandte Chemie, 2015
AbstractFirst evidence for the existence of free trifluoromethyl anion CF3− has been obtained. The 3D‐caged potassium cation in [K(crypt‐222)]+ is inaccessible to CF3−, thus rendering it uncoordinated (“naked”). Ionic [K(crypt‐222)]+ CF3− has been characterized by single‐crystal X‐ray diffraction, solution NMR spectroscopy, DFT calculations, and ...
Anton, Lishchynskyi, Fedor M, Miloserdov, Eddy, Martin, Jordi, Benet-Buchholz, Eduardo C, Escudero-Adán, Andrey I, Konovalov, Vladimir V, Grushin   +6 more
openaire   +2 more sources

Direct Preparation of Trifluoromethyl Ketones from Carboxylic Esters: Trifluoromethylation with (Trifluoromethyl)trimethylsilane

Angewandte Chemie International Edition, 1998
Previously difficult to prepare, aliphatic and alicyclic trifluoromethylketones (e.g. 1 and 2), which are of pharmacalogic interest as potential enzyme inhibitors, can now be synthesized easily and efficiently. The one-step reaction starting with carbonic esters and trimethyl(trifluoromethyl)silane is induced by tetrabutylammonium fluoride in nonpolar,
Jürgen, Wiedemann, Thomas, Heiner, Gregorz, Mloston, G K Surya, Prakash, George A, Olah   +4 more
openaire   +2 more sources

Trifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones

Organic Letters, 2021
The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ...
Xue Liu, Long Liu, Tianzeng Huang, Jingjing Zhang, Zhi Tang, Chunya Li, Tieqiao Chen   +6 more
openaire   +2 more sources

(Trifluoromethyl)sulfenyl, (trifluoromethyl)sulfinyl, and (trifluoromethyl)sulfonyl derivatives of heterocyclic amines

Inorganic Chemistry, 1985
Synthese des composes N-trifluoromethanesulfenyles par action du chlorure de trifluoromethanesulfenyl sur les heterocycles suivants: piperazine(A), tetraaza-1,4,8,11cyclotetradecane(B), hexamethylcyclotrisilazane(C), octamethylcyclotetrasilazane, triaza-1,8,10bora-9decaline, triaza-1,4,8cycloundecane et tetraaza-1,4,7,10cyclododecane; synthese des ...
O. D. Gupta, Wan Ahmad Kamil, Jean'ne M. Shreeve   +2 more
openaire   +1 more source

Trifluoromethylation of aliphatic halides with trifluoromethyl copper

Tetrahedron Letters, 1979
Abstract A solution of trifluoromethyl copper complex in hexamethylphosphoric triamide was found to be useful for trifluoromethylation of aliphatic halides.
Yoshiro Kobayashi, Kenjiro Yamamoto, Itsumaro Kumadaki   +2 more
openaire   +1 more source

Trifluoromethylation recations through trifluoromethyl radical

SCIENTIA SINICA Chimica, 2012
Organic molecules that contain trifluoromethyl group have found wide applications in diverse areas such as functional materials, agrochemicals, pharmaceuticals and so on. Consequently, the development of novel methods of trifluoromethylation has become a hot topic in recent years.
Xi WANG, JianBo WANG, Yan ZHANG
openaire   +1 more source

Nucleophilic Trifluoromethylation Using Trifluoromethyl Iodide. A New and Simple Alternative for the Trifluoromethylation of Aldehydes and Ketones

Organic Letters, 2001
A novel method for nucleophilic trifluoromethylation of aldehydes and ketones, based on photoinduced reduction of trifluoromethyl iodide by tetrakis(dimethylamino)ethylene (TDAE), is presented. [reaction: see text]
S, Aït-Mohand, N, Takechi, M, Médebielle, W R, Dolbier   +3 more
openaire   +2 more sources

Copper-Mediated Trifluoromethylation Using Phenyl Trifluoromethyl Sulfoxide

Organic Letters, 2014
A new method for the generation of trifluoromethylcopper ("CuCF3") species from readily available phenyl trifluoromethyl sulfoxide has been developed. The "CuCF3" reagent can be applied in efficient trifluoromethylations of aryl iodides and activated aryl bromides in the absence of additional ligands.
Xinjin, Li, Jingwei, Zhao, Liang, Zhang, Mingyou, Hu, Limin, Wang, Jinbo, Hu   +5 more
openaire   +2 more sources

2-Trifluoromethylated Indoles via Radical Trifluoromethylation of Isonitriles

Organic Letters, 2014
Either two or three C-C bonds are formed in the synthesis of 2-trifluoromethylindoles starting with readily prepared isonitriles and the Togni reagent as CF3 radical precursor. These transformations occur in the absence of transition metal, and products are obtained in moderate to good yields with excellent diastereoselectivity.
Bo, Zhang, Armido, Studer
openaire   +2 more sources

Electrochemical Trifluoromethylation of Glycals

The Journal of Organic Chemistry, 2021
Carbohydrates play essential roles in various physiological and pathological processes. Trifluoromethylated compounds have wide applications in the field of medicinal chemistry. Herein, we report a practical and efficient trifluoromethylation of glycals by an electrochemical approach using CF3SO2Na as the trifluoromethyl source and MnBr2 as the redox ...
Miao Liu, Zhao-Xiang Luo, Tian Li, De-Cai Xiong, Xin-Shan Ye   +4 more
openaire   +2 more sources