Results 1 to 10 of about 698,346 (390)

Triglyceride and Triglyceride-Rich Lipoproteins in Atherosclerosis

Frontiers in Molecular Biosciences, 2022
Cardiovascular disease (CVD) is still the leading cause of death globally, and atherosclerosis is the main pathological basis of CVDs. Low-density lipoprotein cholesterol (LDL-C) is a strong causal factor of atherosclerosis. However, the first-line lipid-lowering drugs, statins, only reduce approximately 30% of the CVD risk.
Bai-Hui Zhang, Fan Yin, Ya-Nan Qiao, Shou-Dong Guo   +3 more
openaire   +4 more sources

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking [PDF]

Open Biology, 2016
Lipoprotein lipase (LPL) is a rate-limiting enzyme for hydrolysing circulating triglycerides (TG) into free fatty acids that are taken up by peripheral tissues.
Ren Zhang
doaj   +2 more sources

A novel homozygous missense mutation in PNPLA2 in a patient manifesting primary triglyceride deposit cardiomyovasculopathy

Molecular Genetics and Metabolism Reports, 2023
Primary triglyceride deposit cardiomyovasculopathy (P-TGCV), caused by a rare genetic mutation in PNPLA2 encoding adipose triglyceride lipase (ATGL), exhibits severe cardiomyocyte steatosis and heart failure. Here, we report the case of a 51-year-old man
Yasuhiro Hara, Yoshihiko Ikeda, Hayato Kimura, Shinsaku Shimamoto, Mao Ishikawa, Kunihisa Kobayashi, Hironori Nagasaka, Hisashi Shimoyama, Ken-ichi Hirano   +8 more
doaj   +1 more source

Knockdown of lnc-KCNC3-3:1 Alleviates the Development of Atherosclerosis via Downregulation of JAK1/STAT3 Signaling Pathway

Frontiers in Cardiovascular Medicine, 2021
Background: Atherosclerosis is a major cause of coronary artery disease (CAD), and CAD is one of the main causes leading to death in most countries. It has been reported that lncRNAs play important roles in the development of atherosclerosis; thus, we ...
Limin Sun, Xin He, Tao Zhang, Guizhou Tao, Xin Wang   +4 more
doaj   +1 more source

Lipids and Lipoproteins in Health and Disease: Focus on Targeting Atherosclerosis

Biomedicines, 2021
Despite advances in pharmacotherapy, intervention devices and techniques, residual cardiovascular risks still cause a large burden on public health. Whilst most guidelines encourage achieving target levels of specific lipids and lipoproteins to reduce ...
Chih-Kuo Lee, Che-Wei Liao, Shih-Wei Meng, Wei-Kai Wu, Jiun-Yang Chiang, Ming-Shiang Wu   +5 more
doaj   +1 more source

Changing pleural fluid triglyceride levels in cirrhotic chylothorax

Respirology Case Reports, 2022
Chylothorax is an uncommon disease entity, but it occasionally poses a diagnostic challenge to physicians. Pleural fluid triglyceride level has been advocated as a screening test to diagnose chylothorax. However, its level can be depressed if there is an
Ka Pang Chan, Wing Ho Yip, Tina Yee Ching Chan, Chun‐Yiu Law   +3 more
doaj   +1 more source

The nonlinear correlation between the cardiometabolic index and the risk of diabetes: A retrospective Japanese cohort study

Frontiers in Endocrinology, 2023
BackgroundThe cardiometabolic index (CMI) has been proposed as a novel indicator of cardiometabolic status. However, evidence on the relationship between CMI and diabetes mellitus (DM) risk was limited. Our study aimed to explore the relationship between
Fubing Zha, Fubing Zha, Changchun Cao, Mengru Hong, Huili Hou, Qionghua Zhang, Bin Tang, Haofei Hu, Yong Han, Yibing Zan, Yulong Wang, Jianwen Xu   +11 more
doaj   +1 more source

Influence of Extra Virgin Olive Oil Supplement and Combined Exercise on Health-Related Physical Fitness, Cardiovascular Disease Risk Factors, and Bone Density in Obese Elementary Students [PDF]

운동과학, 2020
PURPOSE The purpose of this study was to investigate the influence of combined exercise and extra virgin olive oil supplement on health-related physical fitness, cardiovascular disease risk factors, and bone density in obese elementary school students ...
Kyong-Tae Kim, Ki-Hyuk Lee
doaj   +1 more source

Differential Roles of Two Leptin Gene Paralogues on Food Intake and Hepatic Metabolism Regulation in Mandarin Fish

Frontiers in Endocrinology, 2020
Leptin affects food intake regulation and energy homeostasis in mammals, as opposed to mammals who have a single leptin gene, fish have duplicated leptin gene paralogues.
Xiao-Chen Yuan, Xiao-Chen Yuan, Xu-Fang Liang, Xu-Fang Liang, Wen-Jing Cai, Wen-Jing Cai, Ai-Xuan Li, Ai-Xuan Li, Dong Huang, Dong Huang, Shan He, Shan He   +11 more
doaj   +1 more source

Triglyceride deposit cardiomyovasculopathy: a rare cardiovascular disorder

Orphanet Journal of Rare Diseases, 2019
Triglyceride deposit cardiomyovasculopathy (TGCV) is a phenotype primarily reported in patients carrying genetic mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) which releases long chain fatty acid (LCFA) as a major energy source by the ...
Ming Li, Ken-ichi Hirano, Yoshihiko Ikeda, Masahiro Higashi, Chikako Hashimoto, Bo Zhang, Junji Kozawa, Koichiro Sugimura, Hideyuki Miyauchi, Akira Suzuki, Yasuhiro Hara, Atsuko Takagi, Yasuyuki Ikeda, Kazuhiro Kobayashi, Yoshiaki Futsukaichi, Nobuhiro Zaima, Satoshi Yamaguchi, Rojeet Shrestha, Hiroshi Nakamura, Katsuhiro Kawaguchi, Eiryu Sai, Shu-Ping Hui, Yusuke Nakano, Akinori Sawamura, Tohru Inaba, Yasuhiko Sakata, Yoko Yasui, Yasuyuki Nagasawa, Shintaro Kinugawa, Kazunori Shimada, Sohsuke Yamada, Hiroyuki Hao, Daisaku Nakatani, Tomomi Ide, Tetsuya Amano, Hiroaki Naito, Hironori Nagasaka, Kunihisa Kobayashi, on behalf of the Japan TGCV study group   +38 more
doaj   +1 more source